In vitro Vasorelaxant Effect of Artemisia herba alba Asso. in Spontaneously Hypertensive Rats

Title:In vitro Vasorelaxant Effect of Artemisia herba alba Asso. in Spontaneously Hypertensive Rats

Volume: 14 Issue: 3

Author(s): Zeggwagh Naoufel, Morad Hebi, Mohammed Ajebli, Jean B. Michel and Mohamed Eddouks

Affiliation:

Keywords: Aortic rings, Artemisia herba alba, endothelium vasorelaxant factors, ethnophamacology, hypertension, nitric oxide synthesis.

Abstract: Background: The present study aims to evaluate the in vitro vasorelaxant effect of Artemisia herba alba (Ah) aqueous extract.

Method: Aortic rings were isolated from spontaneously hypertensive rats and incubated in aqueous Ah extract at the following doses: 3, 5, 10 and 20 mg/ml. Incubation of aqueous Ah extract for 30 minutes produced a significant shift of the dose response curve to Norepinephrine (NE) (10^-8 to 10^-5 M) (p<0.001).

Results: Endothelium ablation significantly reduced the vasorelaxant effect of aqueous Ah extract (p<0.001). In addition, inhibition of vascular nitric oxide by N^ω-Nitro-L-Arginine Methyl (LNAME) produced a significant reduction in the vasorelaxant effect of aqueous Ah extract (p<0.001).

Conclusion: We conclude that aqueous Ah extract at a dose of 20 mg/ml possess an in vitro vasorelaxant effect which seems to be dependent on the endothelium vasorelaxant factors involving nitric oxide synthesis.

Cite this article as:

Naoufel Zeggwagh, Hebi Morad, Ajebli Mohammed, Michel B. Jean and Eddouks Mohamed, In vitro Vasorelaxant Effect of Artemisia herba alba Asso. in Spontaneously Hypertensive Rats, Cardiovascular & Hematological Agents in Medicinal Chemistry 2016; 14 (3) . https://dx.doi.org/10.2174/1871525714666161216100044

DOI https://dx.doi.org/10.2174/1871525714666161216100044	Print ISSN 1871-5257
Publisher Name Bentham Science Publisher	Online ISSN 1875-6182