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Current Protein & Peptide Science

Editor-in-Chief

ISSN (Print): 1389-2037
ISSN (Online): 1875-5550

Review Article

Parvalbumin as a Pleomorphic Protein

Author(s): Eugene A. Permyakov*, Vladimir N. Uversky and Sergei E. Permyakov

Volume 18, Issue 8, 2017

Page: [780 - 794] Pages: 15

DOI: 10.2174/1389203717666161213115746

Price: $65

Abstract

Parvalbumin (PA) is a classical small, mostly cytosolic Ca2+-binding protein of the EF-hand superfamily expressed in vertebrates in a tissue- and cell-specific manner, serving as a magnesium/ calcium buffer. In the last decade novel data were published on structural peculiarities of PA, likely affecting its functionality. This review sums up these findings and discusses their potential physiological significance.

Keywords: Parvalbumin, oncomodulin, metal binding, protein unfolding, protein isoforms, structural microheterogeneity, intrinsically disordered protein, antioxidant activity, allergen.

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