Abstract
Pediatric cancer has undergone significant improvements in survival over the past several decades, in part due to a better understanding of the underlying genetic aberrations of each oncologic diagnosis, which has allowed for more effective targeted therapies. Pediatric brain tumors, leukemia, lymphoma, Wilms tumor, and retinoblastoma are exemplary pediatric cancers that each has specific epidemiology regarding children at risk as well as characteristic associated genetic lesions. These genetic features are more commonly being used to provide risk stratification, as well as to identify novel pathways for targeted therapy. With these advances, the overall survival of pediatric cancers continues to be improved.
Keywords: Brain tumors, cancer, genetics, leukemia, lymphoma, pediatrics, retinoblastoma, wilms tumor.
Current Pediatric Reviews
Title:Five Pediatric Cancers – Update on Genetic Implications
Volume: 13 Issue: 1
Author(s): Stacy Cooper, Jeffrey Rubens and Joann Bodurtha*
Affiliation:
- McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins School of Medicine, 600 N. Wolfe St., Blalock 1008, Baltimore MD 21287,United States
Keywords: Brain tumors, cancer, genetics, leukemia, lymphoma, pediatrics, retinoblastoma, wilms tumor.
Abstract: Pediatric cancer has undergone significant improvements in survival over the past several decades, in part due to a better understanding of the underlying genetic aberrations of each oncologic diagnosis, which has allowed for more effective targeted therapies. Pediatric brain tumors, leukemia, lymphoma, Wilms tumor, and retinoblastoma are exemplary pediatric cancers that each has specific epidemiology regarding children at risk as well as characteristic associated genetic lesions. These genetic features are more commonly being used to provide risk stratification, as well as to identify novel pathways for targeted therapy. With these advances, the overall survival of pediatric cancers continues to be improved.
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Cite this article as:
Cooper Stacy, Rubens Jeffrey and Bodurtha Joann*, Five Pediatric Cancers – Update on Genetic Implications, Current Pediatric Reviews 2017; 13 (1) . https://dx.doi.org/10.2174/1573396312666161213114223
DOI https://dx.doi.org/10.2174/1573396312666161213114223 |
Print ISSN 1573-3963 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6336 |
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