Abstract
Background: Acute-onset postoperative endophthalmitis is an uncommon but potentially serious complication of cataract surgery. Since there are relatively few randomized clinical trials comparing the timing and administration of prophylactic antibiotics, there are wide variations in prevention practices around the world.
Methods: Literature review. Results: Antibiotics may be used before surgery, during surgery, or after surgery in an attempt to decrease the rates of endophthalmitis. Antibiotics may be delivered by various routes, including topical, subconjunctival, in the irrigating solution, or by bolus intracameral injection. Polymerase chain reaction and other DNA identification techniques for bacterial isolates and their antibiotic sensitivity profiles will play an important role in future management strategies. Conclusion: There is no consensus regarding the precise use of antibiotics in the perioperative period. Because of increased multidrug-resistant bacteria, evolving strategies are needed to address these issues.Keywords: Endophthalmitis, Endophthalmitis Vitrectomy Study (EVS), Intracameral antibiotics, Cefuroxime, Polymerase chain reaction.
Current Pharmaceutical Design
Title:Hot Topics in Perioperative Antibiotics for Cataract Surgery
Volume: 23 Issue: 4
Author(s): Patrycja Kuklo, Andrzej Grzybowski, Stephen G. Schwartz, Harry W. Flynn and Avinash Pathengay
Affiliation:
Keywords: Endophthalmitis, Endophthalmitis Vitrectomy Study (EVS), Intracameral antibiotics, Cefuroxime, Polymerase chain reaction.
Abstract: Background: Acute-onset postoperative endophthalmitis is an uncommon but potentially serious complication of cataract surgery. Since there are relatively few randomized clinical trials comparing the timing and administration of prophylactic antibiotics, there are wide variations in prevention practices around the world.
Methods: Literature review. Results: Antibiotics may be used before surgery, during surgery, or after surgery in an attempt to decrease the rates of endophthalmitis. Antibiotics may be delivered by various routes, including topical, subconjunctival, in the irrigating solution, or by bolus intracameral injection. Polymerase chain reaction and other DNA identification techniques for bacterial isolates and their antibiotic sensitivity profiles will play an important role in future management strategies. Conclusion: There is no consensus regarding the precise use of antibiotics in the perioperative period. Because of increased multidrug-resistant bacteria, evolving strategies are needed to address these issues.Export Options
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Cite this article as:
Kuklo Patrycja, Grzybowski Andrzej, Schwartz G. Stephen, Flynn W. Harry and Pathengay Avinash, Hot Topics in Perioperative Antibiotics for Cataract Surgery, Current Pharmaceutical Design 2017; 23 (4) . https://dx.doi.org/10.2174/1381612822666161208095348
DOI https://dx.doi.org/10.2174/1381612822666161208095348 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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