Chemistry of Heterocyclic Five and Six Membered Enamino Nitriles and Enamino Esters

Title:Chemistry of Heterocyclic Five and Six Membered Enamino Nitriles and Enamino Esters

Volume: 18 Issue: 12

Author(s): Moustafa Sherief Moustafa*, Saleh Mohammed Al-Mousawi*, Hesham R. El-Seedi*Mohamed Hilmy Elnagdi

Affiliation:

• Department of Chemistry, Faculty of Science; University of Kuwait: Safat; 13060, P.O. Box 5969,Kuwait

• Department of Chemistry, Faculty of Science; University of Kuwait: Safat; 13060, P.O. Box 5969,Kuwait

• Division of Pharmacognosy, Department of Medicinal Chemistry, Uppsala University, Biomedical Centre, Box 574, SE-751 23, Uppsala,Sweden

Keywords: Cyclic enamines, cycloaddition, electrophiles, nucleophiles, functionally substituted enamines, biological activity.

Abstract: Progress in the chemistry of cyclic enamino-nitriles based on the advanced synthetic methodologies is reported. Due to the recent accomplishment, it becomes possible to reactivate these molecules toward electrophiles, nucleophiles and as electron rich dienes in 2+3 dipolar additions and in 4+2 cycloadditions reactions. Synthesizing the poly functionalized 4H-pyrans and their fused derivatives is a fascinating field with a multitude of biological implications such as antitumor, cardiotonic, hepatoprotective, antihypertensive, antibronchitis, as well antifungal activity. This work was conducted with particular emphasis on reviewing the work done on the cyclic enamines since 1990 up till now in order to highlight in more details the synthetic pathways, interactions and the biological activities, Furthermore; we referred to the recent original data of our group contributions within this field.

Cite this article as:

Moustafa Sherief Moustafa*, Al-Mousawi Mohammed Saleh*, El-Seedi R. Hesham*, Elnagdi Hilmy Mohamed, Chemistry of Heterocyclic Five and Six Membered Enamino Nitriles and Enamino Esters, Mini-Reviews in Medicinal Chemistry 2018; 18 (12) . https://dx.doi.org/10.2174/1389557516666161130100610