Abstract
Background: The genus Piper L. has the shikimic acid pathway predominantly expressed, biosynthesizing many cinnamic acid derivatives (CAD).
Objective: Neolignans comprise an important class of CAD that exhibit a wide range of pharmacological properties such as antibacterial, antitumor, insecticidal, anti-inflammatory, antioxidant, smooth muscle relaxant, neuroprotective, antiprotozoal and against platelet aggregation factor. These substances have been extracted and isolated from Piper species using different technics. Results: The present review aims to summarize extraction and isolation methods and biological activities of the different types of neolignans covering the period from 1968 to January 2016.Keywords: Biological activity, extraction, isolation, natural products, neolignans, Piper, Piperaceae.
Mini-Reviews in Medicinal Chemistry
Title:An Overview of Neolignans of the Genus Piper L.: Isolation Methods and Biological Activities
Volume: 17 Issue: 8
Author(s): Arthur Ladeira Macedo, Thais Carvalho Costa dos Santos, Alessandra Leda Valverde, Davyson de Lima Moreira and Thatyana Rocha Alves Vasconcelos*
Affiliation:
- Departmento de Quimica Organica, Instituto de Quimica, Universidade Federal Fluminense, CEP: 24020-141, Niteroi,Brazil
Keywords: Biological activity, extraction, isolation, natural products, neolignans, Piper, Piperaceae.
Abstract: Background: The genus Piper L. has the shikimic acid pathway predominantly expressed, biosynthesizing many cinnamic acid derivatives (CAD).
Objective: Neolignans comprise an important class of CAD that exhibit a wide range of pharmacological properties such as antibacterial, antitumor, insecticidal, anti-inflammatory, antioxidant, smooth muscle relaxant, neuroprotective, antiprotozoal and against platelet aggregation factor. These substances have been extracted and isolated from Piper species using different technics. Results: The present review aims to summarize extraction and isolation methods and biological activities of the different types of neolignans covering the period from 1968 to January 2016.Export Options
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Cite this article as:
Macedo Ladeira Arthur, dos Santos Carvalho Costa Thais, Valverde Leda Alessandra, Moreira de Lima Davyson and Vasconcelos Rocha Alves Thatyana*, An Overview of Neolignans of the Genus Piper L.: Isolation Methods and Biological Activities, Mini-Reviews in Medicinal Chemistry 2017; 17 (8) . https://dx.doi.org/10.2174/1389557516666161130094826
DOI https://dx.doi.org/10.2174/1389557516666161130094826 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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