Abstract
Background: Glucocorticoids (GCs) are largely used in different inflammatory, autoimmune and proliferative diseases. To date their mechanism of action is not completely clear and more studies are necessary, in particular to explain the great interindividual variability in clinical response. In this panorama the glucocorticoid receptor (GR) has an important role: in fact it regulates the pharmacological response thanks to the capability to interact with different molecules (DNA, RNA, ncRNA and proteins) that are known to influence its activity.
Results: In this review our aim is to highlight the knowledge about the role of protein-protein, RNAprotein interactions and epigenetic modifications on the GR and the consequent response to GCs. The characteristics of these interactions with the GR and their effects on the pharmacological activity of GCs will be examined. Conclusion: This information could contribute to the prediction of individual sensitivity to steroids through the identification of new markers of GC resistance. In addition this knowledge may be used in developing new strategies for targeted therapy.Keywords: Biomarkers, epigenetic, glucocorticoid, glucocorticoid receptor, protein-protein interactions, RNA-protein interactions, sensitivity.
Mini-Reviews in Medicinal Chemistry
Title:Glucocorticoid Receptor Interacting Co-regulators: Putative Candidates for Future Drug Targeting Therapy
Volume: 17 Issue: 8
Author(s): Alessia Di Silvestre, Marianna Lucafo, Sara De Iudicibus, Alessandro Ventura, Stefano Martelossi, Gabriele Stocco and Giuliana Decorti*
Affiliation:
- Department of Life Sciences, University of Trieste, Via Alexander Fleming, 22, 34127 Trieste,Italy
Keywords: Biomarkers, epigenetic, glucocorticoid, glucocorticoid receptor, protein-protein interactions, RNA-protein interactions, sensitivity.
Abstract: Background: Glucocorticoids (GCs) are largely used in different inflammatory, autoimmune and proliferative diseases. To date their mechanism of action is not completely clear and more studies are necessary, in particular to explain the great interindividual variability in clinical response. In this panorama the glucocorticoid receptor (GR) has an important role: in fact it regulates the pharmacological response thanks to the capability to interact with different molecules (DNA, RNA, ncRNA and proteins) that are known to influence its activity.
Results: In this review our aim is to highlight the knowledge about the role of protein-protein, RNAprotein interactions and epigenetic modifications on the GR and the consequent response to GCs. The characteristics of these interactions with the GR and their effects on the pharmacological activity of GCs will be examined. Conclusion: This information could contribute to the prediction of individual sensitivity to steroids through the identification of new markers of GC resistance. In addition this knowledge may be used in developing new strategies for targeted therapy.Export Options
About this article
Cite this article as:
Di Silvestre Alessia, Lucafo Marianna, De Iudicibus Sara, Ventura Alessandro, Martelossi Stefano, Stocco Gabriele and Decorti Giuliana*, Glucocorticoid Receptor Interacting Co-regulators: Putative Candidates for Future Drug Targeting Therapy, Mini-Reviews in Medicinal Chemistry 2017; 17 (8) . https://dx.doi.org/10.2174/1389557516666161130094255
DOI https://dx.doi.org/10.2174/1389557516666161130094255 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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