Abstract
Oral diseases like dental caries and periodontal disease are directly associated with the capability of bacteria to form biofilm. Periodontal diseases have been associated to anaerobic Gram-negative bacteria forming a subgingival plaque (Porphyromonas gingivalis, Actinobacillus, Prevotella and Fusobacterium). Biofilm is a complex bacterial community that is highly resistant to antibiotics and human immunity. Biofilm communities are the causative agents of biological developments such as dental caries, periodontitis, peri-implantitis and causing periodontal tissue breakdown. The review recapitulates the latest advancements in treatment of clinical biofilm infections and scientific investigations, while these novel anti-biofilm strategies are still in nascent phases of development, efforts dedicated to these technologies could ultimately lead to anti-biofilm therapies that are superior to the current antibiotic treatment. This paper provides a review of the literature focusing on the studies on biofilm in the oral cavity, formation of dental plaque biofilm, drug resistance of bacterial biofilm and the antibiofilm approaches as biofilm preventive agents in dentistry, and their mechanism of biofilm inhibition.
Keywords: Dental caries, periodontal disease, anti-biofilm approaches, antibiotic.
Current Pharmaceutical Design
Title:Biofilm-mediated Antibiotic-resistant Oral Bacterial Infections: Mechanism and Combat Strategies
Volume: 23 Issue: 14
Author(s): Indulata Kanwar, Abhishek K. Sah and Preeti K. Suresh*
Affiliation:
- University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur-492010, Chhattisgarh,India
Keywords: Dental caries, periodontal disease, anti-biofilm approaches, antibiotic.
Abstract: Oral diseases like dental caries and periodontal disease are directly associated with the capability of bacteria to form biofilm. Periodontal diseases have been associated to anaerobic Gram-negative bacteria forming a subgingival plaque (Porphyromonas gingivalis, Actinobacillus, Prevotella and Fusobacterium). Biofilm is a complex bacterial community that is highly resistant to antibiotics and human immunity. Biofilm communities are the causative agents of biological developments such as dental caries, periodontitis, peri-implantitis and causing periodontal tissue breakdown. The review recapitulates the latest advancements in treatment of clinical biofilm infections and scientific investigations, while these novel anti-biofilm strategies are still in nascent phases of development, efforts dedicated to these technologies could ultimately lead to anti-biofilm therapies that are superior to the current antibiotic treatment. This paper provides a review of the literature focusing on the studies on biofilm in the oral cavity, formation of dental plaque biofilm, drug resistance of bacterial biofilm and the antibiofilm approaches as biofilm preventive agents in dentistry, and their mechanism of biofilm inhibition.
Export Options
About this article
Cite this article as:
Kanwar Indulata, Sah K. Abhishek and Suresh K. Preeti*, Biofilm-mediated Antibiotic-resistant Oral Bacterial Infections: Mechanism and Combat Strategies, Current Pharmaceutical Design 2017; 23 (14) . https://dx.doi.org/10.2174/1381612822666161124154549
DOI https://dx.doi.org/10.2174/1381612822666161124154549 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Medium-Term Culture of Primary Oral Squamous Cell Carcinoma in a Three- Dimensional Model: Effects on Cell Survival Following Topical 5-Fluororacile Delivery by Drug-Loaded Matrix Tablets
Current Pharmaceutical Design Alpha-1 Antitrypsin: It’s Role in Health and Disease
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Periodontitis, Endothelial Dysfunction and Atherosclerosis
Vascular Disease Prevention (Discontinued) MiR-106a Associated with Diabetic Peripheral Neuropathy Through the Regulation of 12/15-LOX-meidiated Oxidative/Nitrative Stress
Current Neurovascular Research Proteomics and Epigenetic Mechanisms in Stem Cells
Current Proteomics Formulation Development of Nanoparticulate Periodontal Drug Delivery System of Metronidazole Benzoate with Combination Processing Method by Using Design of Experiment
Micro and Nanosystems Matrix Metalloproteinases as Drug Targets in Acute Pulmonary Embolism
Current Drug Targets MMP-2 Selectivity in Hydroxamate-Type Inhibitors
Current Medicinal Chemistry Nanoplatforms for Promoting Osteogenesis in Ovariectomy-Induced Osteoporosis in the Experimental Model
Current Nanomedicine The Inflammation Paradigm and Coronary Artery Disease: What Celsus, Virchow and Gene Knock Outs Have Taught Us
Cardiovascular & Hematological Disorders-Drug Targets Evaluation of Salivary Lipid Peroxidation End Product Level in Dental Caries
Infectious Disorders - Drug Targets Chronic Diseases and COVID-19: A Review
Endocrine, Metabolic & Immune Disorders - Drug Targets Impact of Different Implant Surfaces Topographies on Peri-Implant Tissues: An Update of Current Available Data on Dental Implants Retrieved from Human Jaws
Current Pharmaceutical Biotechnology The Possible Role of Pathogenic and Non-Pathogenic Bacteria in Initiation and Exacerbation of Celiac Disease; A Comprehensive Review
Current Pharmaceutical Biotechnology Epigenetic Regulations in the Pathogenesis of Periodontitis
Current Stem Cell Research & Therapy Current and Future Challenges in Primary Sjogren’s Syndrome
Current Pharmaceutical Biotechnology Mucoadhesive Polymers for Oral Transmucosal Drug Delivery: A Review
Current Pharmaceutical Design Teeth: Small but Mighty and Mighty Important. A Comprehensive Review of Children’s Dental Health for Primary Care Clinicians
Current Pediatric Reviews The Infectious Etiology of Alzheimer’s Disease
Current Neuropharmacology Refractory Angina Pectoris: Lessons from the Past and Current Perspectives
Current Pharmaceutical Design