Abstract
With the rapid development of targeted therapy and our understanding of the underlying molecular mechanisms, drug repurposing is becoming trendy in drug development field. Drugs that display promising therapeutic effects towards multiple diseases tend to target important signaling proteins. Insulin resistance and obesity are strongly associated and both are reported to be correlated with cancer, suggesting they may be linked via some critical pathways. Signal transducer and activator of transcription 1 (STAT1) is an important transcription factor involved in the regulation of multiple cellular processes such as proliferation, survival, inflammation, and angiogenesis. The expression and activity of STAT1 is misregulated in both insulin resistance diseases and cancer. In this review, we summarize recent progress on the function and regulation of STAT1 in both cancer and insulin resistance diseases. Drugs and small molecules that can interfere with STAT1 activity or expression are also discussed.
Keywords: STAT1, Cancer, insulin resistance diseases, signalling pathway.
Current Protein & Peptide Science
Title:Targeting STAT1 in Both Cancer and Insulin Resistance Diseases
Volume: 18 Issue: 2
Author(s): Chen Meng, Li-bin Guo, Xiaolong Liu, Yih-Hsin Chang and Yao Lin
Affiliation:
Keywords: STAT1, Cancer, insulin resistance diseases, signalling pathway.
Abstract: With the rapid development of targeted therapy and our understanding of the underlying molecular mechanisms, drug repurposing is becoming trendy in drug development field. Drugs that display promising therapeutic effects towards multiple diseases tend to target important signaling proteins. Insulin resistance and obesity are strongly associated and both are reported to be correlated with cancer, suggesting they may be linked via some critical pathways. Signal transducer and activator of transcription 1 (STAT1) is an important transcription factor involved in the regulation of multiple cellular processes such as proliferation, survival, inflammation, and angiogenesis. The expression and activity of STAT1 is misregulated in both insulin resistance diseases and cancer. In this review, we summarize recent progress on the function and regulation of STAT1 in both cancer and insulin resistance diseases. Drugs and small molecules that can interfere with STAT1 activity or expression are also discussed.
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Cite this article as:
Meng Chen, Guo Li-bin, Liu Xiaolong, Chang Yih-Hsin and Lin Yao, Targeting STAT1 in Both Cancer and Insulin Resistance Diseases, Current Protein & Peptide Science 2017; 18 (2) . https://dx.doi.org/10.2174/1389203718666161117114735
DOI https://dx.doi.org/10.2174/1389203718666161117114735 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
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