Abstract
Throughout the development of medicine, the spotlight has been held by the search for new drugs blocking different types of arrhythmia. In the past decade, much attention was given to the selection of active antiarrhythmic substances from plant material. It has been shown that these compounds have a good antiarrhythmic effect, and their chemical modifications substantially increase their major effects while adding other beneficial pharmacological properties. In this regard, work on the chemical modification of plant-source antiarrhythmics is highly relevant to the development of new and promising drugs.
Keywords: Antiarrhythmic drugs, cardiovascular, chemical modifications, ischemic heart disease, plant substances, thyreoidea.
Mini-Reviews in Medicinal Chemistry
Title:Natural Products as a Source of Antiarrhythmic Drugs
Volume: 18 Issue: 4
Author(s): Arkadiy O. Bryzgalov*, Tatjana G. Tolstikova, Elvira E. Shults and Kristina O. Petrova
Affiliation:
- Novosibirsk Institute of Organic Chemistry, Siberian Branch of Russian Academy of Sciences, 9 Prosp. Akad. Lavrentyeva, Novosibirsk 630090,Russian Federation
Keywords: Antiarrhythmic drugs, cardiovascular, chemical modifications, ischemic heart disease, plant substances, thyreoidea.
Abstract: Throughout the development of medicine, the spotlight has been held by the search for new drugs blocking different types of arrhythmia. In the past decade, much attention was given to the selection of active antiarrhythmic substances from plant material. It has been shown that these compounds have a good antiarrhythmic effect, and their chemical modifications substantially increase their major effects while adding other beneficial pharmacological properties. In this regard, work on the chemical modification of plant-source antiarrhythmics is highly relevant to the development of new and promising drugs.
Export Options
About this article
Cite this article as:
Bryzgalov O. Arkadiy*, Tolstikova G. Tatjana, Shults E. Elvira and Petrova O. Kristina, Natural Products as a Source of Antiarrhythmic Drugs, Mini-Reviews in Medicinal Chemistry 2018; 18 (4) . https://dx.doi.org/10.2174/1389557516666161104144815
DOI https://dx.doi.org/10.2174/1389557516666161104144815 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
Call for Papers in Thematic Issues
Bioprospecting of Natural Products as Sources of New Multitarget Therapies
According to the Convention on Biological Diversity, bioprospecting is the exploration of biodiversity and indigenous knowledge to develop commercially valuable products for pharmaceutical and other applications. Bioprospecting involves searching for useful organic compounds in plants, fungi, marine organisms, and microorganisms. Natural products traditionally constituted the primary source of more than ...read more
Computational Frontiers in Medicinal Chemistry
The thematic issue "Computational Frontiers in Medicinal Chemistry" provides a robust platform for delving into state-of-the-art computational methodologies and technologies that significantly propel advancements in medicinal chemistry. This edition seeks to amalgamate top-tier reviews spotlighting the latest trends and breakthroughs in the fusion of computational approaches, including artificial intelligence (AI) ...read more
Mitochondria as a Therapeutic Target in Metabolic Disorders
Mitochondria are the primary site of adenosine triphosphate (ATP) production in mammalian cells. Moreover, these organelles are an important source of reactive oxygen and nitrogen species in virtually any nucleated cell type. The modulation of a myriad of cellular signaling pathways depends on the mitochondrial physiology. Mitochondrial dysfunction is observed ...read more
Natural Products and Dietary Supplements in Alleviation of Metabolic, Cardiovascular, and Neurological Disorders
Metabolic disorders like diabetes, obesity, inflammation, oxidative stress, cancer etc, cardiovascular disorders like angina, myocardial infarction, congestive heart failure etc as well as neurological disorders like Alzheimer?s, Parkinson?s, Epilepsy, Depression, etc are the global burden. They covered the major segment of the diseases and disorders from which the human community ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Ivabradine: A Current Overview
Current Clinical Pharmacology Role of AGEs-RAGE System in Cardiovascular Disease
Current Pharmaceutical Design Mitochondria as a Therapeutic Target for Aging and Neurodegenerative Diseases
Current Alzheimer Research Hypothyroidism and Atherosclerosis-Possible Implication of the Renin-Angiotensin System
Current Hypertension Reviews Systems Biology and Biomechanical Model of Heart Failure
Current Cardiology Reviews Telomerase Therapeutics for Degenerative Diseases
Current Molecular Medicine Role of microRNAs in Vascular Remodeling
Current Molecular Medicine Protecting the Heart: Biological Targets and Clinical Strategies
Current Pharmaceutical Design Cell Based Approaches for Myocardial Regeneration and Artificial Myocardium
Current Stem Cell Research & Therapy Targeting Myocardial Metabolism for the Treatment of Stable Angina
Current Pharmaceutical Design Xanthine Oxidase Inhibitor Febuxostat as a Novel Agent Postulated to Act Against Vascular Inflammation
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Medication Adherence of Patients with Systemic Lupus Erythematosus and Rheumatoid Arthritis Considering the Psychosocial Factors, Health Literacy and Current Life Concerns of Patients
Current Rheumatology Reviews Stem Cell Therapies
Recent Patents on Regenerative Medicine New Trends and Advances in Oral and Maxillofacial Imaging
Current Medical Imaging Prostacyclin, Atherothrombosis and Diabetes Mellitus: Physiologic and Clinical Considerations
Current Molecular Medicine Vascular Endothelin and Hypertension - From Receptors to Medicine
Current Hypertension Reviews Small Molecule Inhibitors of NF-κB and JAK/STAT Signal Transduction Pathways as Promising Anti-Inflammatory Therapeutics
Mini-Reviews in Medicinal Chemistry Erythropoiesis Stimulating Agents and Anaemia of End-Stage Renal Disease
Cardiovascular & Hematological Agents in Medicinal Chemistry Women’s Health in Central America: The Complexity of Issues and the Need to Focus on Indigenous Healthcare
Current Women`s Health Reviews Phytogenic Polyphenols as Glycogen Phosphorylase Inhibitors: The Potential of Triterpenes and Flavonoids for Glycaemic Control in Type 2 Diabetes
Current Medicinal Chemistry