Abstract
Background: Intracerebral hemorrhage (ICH) is a common type of stroke associated with high mortality and morbidity. Recent randomized controlled trials could not prove that the current strategies are effective at improving the final outcome of the ICH patients.
Methods: Here we want to explore potential intervention targets for ICH based on the framework of the vascular neural network (VNN). In this review, a brief history of the evolution of stroke pathophysiology from humoral theory to VNN is discussed. Results: As current literature on pathophysiology of ICH is mainly focused on neuroprotection, here we want to evolve the central paradigm towards VNN. We stress mechanisms of vascular disruption and impaired blood flow harmony, which are clinically relevant but have received less attention in basic research. Conclusion: We propose that VNN could be a robust and practical paradigm in both ICH basic research and clinical practice.Keywords: Intracerebral hemorrhage, vascular neural network, hematoma expansion, perihematomal edema, venous system, stroke pathophysiology.
Current Pharmaceutical Design
Title:Targeting Vascular Neural Network in Intracerebral Hemorrhage
Volume: 23 Issue: 15
Author(s): Yi Yin, Hongfei Ge, John H. Zhang*Hua Feng*
Affiliation:
- Department of Physiology and Pharmacology, Loma Linda University, 11041 Campus Street, Risley Hall, Room 219, Loma Linda, CA 92350,United States
- Department of Neurosurgery, Southwest Hospital, Third Military Medical University, 38 Gaotanyan Street, Chongqing 400038,China
Keywords: Intracerebral hemorrhage, vascular neural network, hematoma expansion, perihematomal edema, venous system, stroke pathophysiology.
Abstract: Background: Intracerebral hemorrhage (ICH) is a common type of stroke associated with high mortality and morbidity. Recent randomized controlled trials could not prove that the current strategies are effective at improving the final outcome of the ICH patients.
Methods: Here we want to explore potential intervention targets for ICH based on the framework of the vascular neural network (VNN). In this review, a brief history of the evolution of stroke pathophysiology from humoral theory to VNN is discussed. Results: As current literature on pathophysiology of ICH is mainly focused on neuroprotection, here we want to evolve the central paradigm towards VNN. We stress mechanisms of vascular disruption and impaired blood flow harmony, which are clinically relevant but have received less attention in basic research. Conclusion: We propose that VNN could be a robust and practical paradigm in both ICH basic research and clinical practice.Export Options
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Cite this article as:
Yin Yi, Ge Hongfei, Zhang H. John*, Feng Hua*, Targeting Vascular Neural Network in Intracerebral Hemorrhage, Current Pharmaceutical Design 2017; 23 (15) . https://dx.doi.org/10.2174/1381612822666161027122821
DOI https://dx.doi.org/10.2174/1381612822666161027122821 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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