Abstract
Background: Besides the well-documented biochemical and electrophysiological effects, the mechanical stimuli also have prominent roles in the initiation and development of brain diseases but yet have been underestimated. To explore the role of mechanical stimuli and the followed mechanical-biochemical effects in the brain diseases.
Method: In this review, we discussed the initiation and effect of mechanical stimuli and the surrounding topography in brain diseases, especially for the intracerebral hemorrhage (ICH), Alzheimer’s disease (AD), diffuse axonal injury (DAI) and primary brain tumors. The induced cascades of biological pathways by mechanical stimuli prior to and during the brain diseases were summarized. Strategies aiming to reduce the mechanical stimuli related damages or poor outcomes were also discussed, despite some could only prevent rather than cure. Literatures have indicated mechanical stimuli were the connection between the exogenous mechanotransduction and the inherent biochemical cascades. Therefore, we also reviewed in vitro models in the literatures that simulated the diverse range of mechanical stimuli, which connected the neural network with the tissue engineering, biomaterials and potential therapeutic strategies together. Results: At the microscopic and macroscopic levels, the hydrostatic pressure, tensile/compressive force, shear force, and even the roughness of topography from the physical surrounding exert the influence on the neural network not only by themselves but also through the interaction with other factors, e.g. biochemical or electrophysiological effects. Conclusion: In the clinical management, taking the undervalued mechanical stimuli and the followed mechanical- biochemical effects into consideration are important and inevitable in preventing and treating brain diseases.Keywords: Mechanical stimuli, brain diseases, intracerebral hemorrhage, Alzheimer’s disease, in vitro models, electrophysiological effects.
Current Pharmaceutical Design
Title:The Underestimated Role of Mechanical Stimuli in Brain Diseases and the Relate d In Vitro Models
Volume: 23 Issue: 15
Author(s): Tingwang Guo, Peng Ren, Shilei Hao*Bochu Wang*
Affiliation:
- Bioengineering College, Chongqing University, No. 174, Shapingba Main Street, Chongqing,China
- Bioengineering College, Chongqing University, No. 174, Shapingba Main Street, Chongqing,China
Keywords: Mechanical stimuli, brain diseases, intracerebral hemorrhage, Alzheimer’s disease, in vitro models, electrophysiological effects.
Abstract: Background: Besides the well-documented biochemical and electrophysiological effects, the mechanical stimuli also have prominent roles in the initiation and development of brain diseases but yet have been underestimated. To explore the role of mechanical stimuli and the followed mechanical-biochemical effects in the brain diseases.
Method: In this review, we discussed the initiation and effect of mechanical stimuli and the surrounding topography in brain diseases, especially for the intracerebral hemorrhage (ICH), Alzheimer’s disease (AD), diffuse axonal injury (DAI) and primary brain tumors. The induced cascades of biological pathways by mechanical stimuli prior to and during the brain diseases were summarized. Strategies aiming to reduce the mechanical stimuli related damages or poor outcomes were also discussed, despite some could only prevent rather than cure. Literatures have indicated mechanical stimuli were the connection between the exogenous mechanotransduction and the inherent biochemical cascades. Therefore, we also reviewed in vitro models in the literatures that simulated the diverse range of mechanical stimuli, which connected the neural network with the tissue engineering, biomaterials and potential therapeutic strategies together. Results: At the microscopic and macroscopic levels, the hydrostatic pressure, tensile/compressive force, shear force, and even the roughness of topography from the physical surrounding exert the influence on the neural network not only by themselves but also through the interaction with other factors, e.g. biochemical or electrophysiological effects. Conclusion: In the clinical management, taking the undervalued mechanical stimuli and the followed mechanical- biochemical effects into consideration are important and inevitable in preventing and treating brain diseases.Export Options
About this article
Cite this article as:
Guo Tingwang, Ren Peng, Hao Shilei*, Wang Bochu*, The Underestimated Role of Mechanical Stimuli in Brain Diseases and the Relate d In Vitro Models, Current Pharmaceutical Design 2017; 23 (15) . https://dx.doi.org/10.2174/1381612822666161027113200
DOI https://dx.doi.org/10.2174/1381612822666161027113200 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
Call for Papers in Thematic Issues
"Tuberculosis Prevention, Diagnosis and Drug Discovery"
The Nobel Prize-winning discoveries of Mycobacterium tuberculosis and streptomycin have enabled an appropriate diagnosis and an effective treatment of tuberculosis (TB). Since then, many newer diagnosis methods and drugs have been saving millions of lives. Despite advances in the past, TB is still a leading cause of infectious disease mortality ...read more
Current Pharmaceutical challenges in the treatment and diagnosis of neurological dysfunctions
Neurological dysfunctions (MND, ALS, MS, PD, AD, HD, ALS, Autism, OCD etc..) present significant challenges in both diagnosis and treatment, often necessitating innovative approaches and therapeutic interventions. This thematic issue aims to explore the current pharmaceutical landscape surrounding neurological disorders, shedding light on the challenges faced by researchers, clinicians, and ...read more
Emerging and re-emerging diseases
Faced with a possible endemic situation of COVID-19, the world has experienced two important phenomena, the emergence of new infectious diseases and/or the resurgence of previously eradicated infectious diseases. Furthermore, the geographic distribution of such diseases has also undergone changes. This context, in turn, may have a strong relationship with ...read more
Melanoma and Non-Melanoma Skin Cancer Treatment: Standard of Care and Recent Advances
In this thematic issue, we aim to provide a standard of care of the diagnosis and treatment of melanoma and non-melanoma skin cancer. The editor will invite authors from different countries who will write review articles of melanoma and non-melanoma skin cancers. The Diagnosis, Staging, Surgical Treatment, Non-Surgical Treatment all ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Steroid Biosynthesis Inhibitors in the Therapy of Hypercortisolism: Theory and Practice
Current Medicinal Chemistry Can PET Imaging Facilitate Optimization of Cancer Therapies?
Current Pharmaceutical Design What Constitutes Prescription Drug Misuse? Problems and Pitfalls of Current Conceptualizations
Current Drug Abuse Reviews Fighting Diabetes: Lessons from Xenotransplantation and Nanomedicine
Current Pharmaceutical Design Differences in Relative Levels of 88 microRNAs in Various Regions of the Normal Adult Human Brain
MicroRNA Positive Social Interactions in a Lifespan Perspective with a Focus on Opioidergic and Oxytocinergic Systems: Implications for Neuroprotection
Current Neuropharmacology Metabolic and Functional Brain Mapping, Connectivity and Plasticity Applied to the Surgery of Cerebral Tumors
Current Medical Imaging Extracellular Vesicles as Novel Delivery Tools for Cancer Treatment
Current Cancer Drug Targets Treatment of Viral Encephalitis
Central Nervous System Agents in Medicinal Chemistry Structural and Functional Organization of miRNAs
Current Pharmacogenomics Manufacturing and Regulatory Strategies for Clinical AAV2-hRPE65
Current Gene Therapy Rediscovering Tocophersolan: A Renaissance for Nano-Based Drug Delivery and Nanotheranostic Applications
Current Drug Targets Action and Disposition of the β3-Agonist Nebivolol in the Presence of Inflammation; An Alternative to Conventional β1-Blockers
Current Pharmaceutical Design CYP3A4-mediated Pharmacokinetic Interactions in Cancer Therapy
Current Drug Metabolism Modified Polysaccharides as Versatile Materials in Controlled Delivery of Antidegenerative Agents
Current Pharmaceutical Design A Focus on Microfluidics and Nanotechnology Approaches for the Ultra Sensitive Detection of MicroRNA
MicroRNA Transdermal Oxandrolone: Ex Vivo Percutaneous Absorption Study
Current Drug Delivery Brain Proton Magnetic Resonance Spectroscopy: A Review of Main Metabolites and its Clinical Applications in Gliomas
Current Molecular Imaging (Discontinued) Iron Chelators for the Treatment of Cancer
Current Medicinal Chemistry Current Clinical Applications of In Vivo Magnetic Resonance Spectroscopy and Spectroscopic Imaging
Current Medical Imaging