Perspectives on Strategies Using Swellable Polymers in Solid Dispersions for Controlled Drug Release

Title:Perspectives on Strategies Using Swellable Polymers in Solid Dispersions for Controlled Drug Release

Volume: 23 Issue: 11

Author(s): Thao T.D. Tran and Phuong H.L. Tran*

Affiliation:

• Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City, Vietnam; Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, Vietnam; School of Medicine, Deakin University, Waurn Ponds, Victoria,Australia

Keywords: Solid dispersion, controlled release, swellable polymers, dissolution rate, poorly water-soluble drugs, bioavailability, poor absorption.

Abstract: Poorly water-soluble drugs, which commonly face the issue of poor absorption and low bioavailability, have been under ongoing research of many formulation scientists for the past few decades. Solid dispersion is one of the most effective strategies in concerns for improving bioavailability of poorly water-soluble drugs. Either application of solid dispersions in dissolution enhancement of poorly water-soluble drugs or the use of swellable polymers in controlled drug release has been reported in pharmaceutical designs widely. However, a review of strategies of using swellable polymers in solid dispersion to take a full advantage of these polymers as a current perspective in facilitating drug bioavailability enhancement is still missing. In this review, we aim to provide a summary of techniques used to formulate a swellable polymer in solid dispersion especially a description of a suitable fabrication method in design of a controlled release solid dispersion.

Cite this article as:

Tran T.D. Thao and Tran H.L. Phuong*, Perspectives on Strategies Using Swellable Polymers in Solid Dispersions for Controlled Drug Release, Current Pharmaceutical Design 2017; 23 (11) . https://dx.doi.org/10.2174/1381612822666161021152932