Umbilical IgE and Advanced Glycation Products in Association with Allergies in Childhood

Title:Umbilical IgE and Advanced Glycation Products in Association with Allergies in Childhood

Volume: 16 Issue: 2

Author(s): Jiri Liska, Vaclav Holecek, Konrad Siala, Stepanka Sobotova, Ladislav Trefil, Jaroslav Racek, Josef Sykora and Franstisek Sefrna

Affiliation:

Keywords: Advanced glycation end products, allergy, neonates, oxidative stress, immunoglobulin E, umbilical blood.

Abstract: Background: Little is known regarding the possibility of predicting allergy in genetically susceptible individuals.

Objective: We endeavored to measure the levels of IgE, IgA and advanced glycation end products (AGEs) in the umbilical blood of newborns of allergic parents.

Method: We collected two groups of newborns, the first group of 20 subjects with nonatopic parents, and the second with 20 subjects with a history of allergy in one or both parents.

Results: Neonates born to parents with allergies had increased levels of AGEs in their umbilical cord blood.

Conclusion: This causes increased oxidative stress and an increased probability of allergy and asthma in a child ´s future. We therefore propose that such children should be followed with the aim of lowering AGEs and IgE throughout life.

Cite this article as:

Liska Jiri, Holecek Vaclav, Siala Konrad, Sobotova Stepanka, Trefil Ladislav, Racek Jaroslav, Sykora Josef and Sefrna Franstisek, Umbilical IgE and Advanced Glycation Products in Association with Allergies in Childhood, Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) 2016; 16 (2) . https://dx.doi.org/10.2174/1871522216666161018145434

DOI https://dx.doi.org/10.2174/1871522216666161018145434	Print ISSN 1871-5222
Publisher Name Bentham Science Publisher	Online ISSN 1875-6115