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Current Organic Synthesis

Editor-in-Chief

ISSN (Print): 1570-1794
ISSN (Online): 1875-6271

Research Article

Synthesis and in vitro Anti-tumor Activity of Some New Sebacoyl Chloride Based Heterocycles

Author(s): Islam H. El Azab* and Nadia A.A. Elkanzi

Volume 14, Issue 2, 2017

Page: [309 - 320] Pages: 12

DOI: 10.2174/1570179413666161008200206

Price: $65

Abstract

Background: N-Heterocycles are of special interest because, many natural and synthetic bioactive compounds are found to be N-containing heterocycles and they constitute an important class of pharmacophores in medicinal chemistry. Recently, 1,2,3-triazoles have been found to possess a vast range of vital applications in the agrochemical, pharmaceutical, and materials field. In addition, various compounds of the 1,2,3-triazole family have shown a broad spectrum of biological properties such as antibacterial, and anti-HIV activity. 1,3,4- Oxadiazoles are important oxygen and nitrogen containing heterocyclic compounds, they possess desirable electronic and charge-transport properties.

Methods: Two mammalian cell lines were grown in RPMI-1640 medium, supplemented with 10% heat inactivated FBS, 50 units/mL of penicillin and 50 g/mL of streptomycin and maintained at 37 °C in a humidified atmosphere containing 5% CO2. The cells were maintained as “monolayer culture” by serial sub-culturing. Preliminary cytotoxicity was performed using SRB method.

Results: Sebacoyl chloride and decanedihydrazide dihydrochloride are utilized as versatile building blocks to annulate a series of novel azole and/ or azine systems. The in vitro anti-tumor activities of the synthesized compounds were evaluated against human breast cancer cell line (MCF-7) and human cervical cancer cell line (HeLa). The obtained data indicated that the majority of the tested compounds possess significant anti-tumor activities against the tested tumor cell lines.

Conclusion: Sebacoyl chloride, decanedihydrazide dihydrochloride and N-nucleophiles are useful precursors for the synthesis of different functionalized N- heterocycles. The cytotoxic study revealed that the majority of the tested compounds possess significant anti-tumor activity towards the tested tumor cell lines.

Keywords: Sebacoyl chloride, acid chloride, decanedihydrazide, azole, N-heterocycles, anti-tumour activity., Sebacoyl chloride, acid chloride, decanedihydrazide, azole, N-heterocycles, anti-tumour activity.

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