Cytotoxic Phyllactone Analogs from the Marine Sponge Phyllospongia papyrecea

Title:Cytotoxic Phyllactone Analogs from the Marine Sponge Phyllospongia papyrecea

Volume: 13 Issue: 3

Author(s): Huawei Zhang*, Phillip Crews, Karen Tenney and Frederick A. Valeriote

Affiliation:

• School of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014,China

Keywords: Marine sponge, Phyllospongia papyrecea, sesterterpene, phyllactone, cytotoxic activity.

Abstract: Background: A growing evidence indicates that marine sponge Phyllospongia sp. is one of rich sources of 20, 24-bishomoscalarane sesterterpenes with potent biological activities. In order to search more bioactive 20, 24-bishomoscalarane sesterterpenes for new drug discovery, chemical investigation was carried out on an Indonesian marine sponge P. papyrecea.

Methods: Bioassay-guided fractionation was carried out on its dichloromethane extract. And nine compounds were purified and isolated using HPLC. Their chemical structures were determined by a combination of spectroscopic and spectrometric data, including 1D-, 2D-NMR and HRESI-MS. Their cytotoxic activities were performed on three human tumor cell lines A549, MCF-7 and HeLa using the CCK-8 method.

Results: One new 20, 24-bishomoscalarane sesterterpene, phyllactone H (9), was isolated and elucidated together with phyllactones A-B (1-2) and D-G (3-6), 12α, 24-dihydroxy-20, 24-dimethyl-15, 17- scalaradien-25, 24-olides (7-8). Compounds 1 and 2, 3 and 4, 5 and 6, 7 and 8 were C-24 anomers and inseparable mixtures, respectively. The 1H and 13C-NMR data for 7/8 were firstly reported in this paper.

Conclusion: Compounds 1-9 possessed in vitro moderate cytotoxicities against A549, MCF-7 and HeLa cells with IC50 values of less than 25 μM.

Cite this article as:

Zhang Huawei*, Crews Phillip, Tenney Karen and Valeriote A. Frederick, Cytotoxic Phyllactone Analogs from the Marine Sponge Phyllospongia papyrecea, Medicinal Chemistry 2017; 13 (3) . https://dx.doi.org/10.2174/1573406412666161007150828

DOI https://dx.doi.org/10.2174/1573406412666161007150828	Print ISSN 1573-4064
Publisher Name Bentham Science Publisher	Online ISSN 1875-6638