Abstract
Background: Our recent findings have demonstrated that electromagnetic radiations (EMR) (1.8 GHz radiofrequency) are able to in vitro induce morphometrical and morphological modifications of human leukocytes from normal donors.
Methods: In view of the evidence that polyphenols exert many beneficial effects on plants, animals and humans, leukocytes from human peripheral blood were pre-treated for 1 h with two polyphenol preparations from red grape before EMR exposure (1.8 GHz). Results: Our data will show that polyphenol pre-treatment reverts to normality the morphology of irradiated leukocytes in comparison to irradiated cells only. Conversely, leukocyte morphometry seems to be not affected by this treatment. Conclusion: Here, we demonstrate that polyphenols are also able to normalize leukocyte morphology per se altered before as well as after irradiation. Finally, a working hypothesis aimed at clarifying the protective mechanisms exerted by polyphenols on irradiated leukocytes will be illustrated.Keywords: Electromagnetic radiations, leukocytes, morphology, morphometry, polyphenols.
Endocrine, Metabolic & Immune Disorders - Drug Targets
Title:Morphometrical and Morphological Alterations of Human Leukocytes Exposed to 1.8 GHz Electromagnetic Radiations: In Vitro Protective Effects Induced by Polyphenols
Volume: 16 Issue: 3
Author(s): Pier Francesco Biagi, Sara Boffola, Riccardo Stefanelli, Luigi Schiavulli, Teresa Ligonzo, Giuseppe Casamassima, Maria Teresa Pappagallo, Kiichiro Kawaguchi, Hiroaki Takimoto, Yoshio Kumazawa, Sergio Fontana, Flavia Laforgia, Matteo Antonio Russo, Thea Magrone and Emilio Jirillo
Affiliation:
Keywords: Electromagnetic radiations, leukocytes, morphology, morphometry, polyphenols.
Abstract: Background: Our recent findings have demonstrated that electromagnetic radiations (EMR) (1.8 GHz radiofrequency) are able to in vitro induce morphometrical and morphological modifications of human leukocytes from normal donors.
Methods: In view of the evidence that polyphenols exert many beneficial effects on plants, animals and humans, leukocytes from human peripheral blood were pre-treated for 1 h with two polyphenol preparations from red grape before EMR exposure (1.8 GHz). Results: Our data will show that polyphenol pre-treatment reverts to normality the morphology of irradiated leukocytes in comparison to irradiated cells only. Conversely, leukocyte morphometry seems to be not affected by this treatment. Conclusion: Here, we demonstrate that polyphenols are also able to normalize leukocyte morphology per se altered before as well as after irradiation. Finally, a working hypothesis aimed at clarifying the protective mechanisms exerted by polyphenols on irradiated leukocytes will be illustrated.Export Options
About this article
Cite this article as:
Biagi Francesco Pier, Boffola Sara, Stefanelli Riccardo, Schiavulli Luigi, Ligonzo Teresa, Casamassima Giuseppe, Pappagallo Teresa Maria, Kawaguchi Kiichiro, Takimoto Hiroaki, Kumazawa Yoshio, Fontana Sergio, Laforgia Flavia, Russo Antonio Matteo, Magrone Thea and Jirillo Emilio, Morphometrical and Morphological Alterations of Human Leukocytes Exposed to 1.8 GHz Electromagnetic Radiations: In Vitro Protective Effects Induced by Polyphenols, Endocrine, Metabolic & Immune Disorders - Drug Targets 2016; 16 (3) . https://dx.doi.org/10.2174/1871530316666161003153024
DOI https://dx.doi.org/10.2174/1871530316666161003153024 |
Print ISSN 1871-5303 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3873 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Effects of Dietary Iron Modulation on Gut Microbial Composition and Function in Monogastrics: A Review
Protein & Peptide Letters Type 2 Diabetes Risk Among University Students in Malaysia
Current Diabetes Reviews Endocannabinoid Receptor Antagonists and Other Emerging Pharmacological Strategies for Weight Reduction
Current Drug Targets - Cardiovascular & Hematological Disorders In vivo MRS of Muscle, Liver, Heart and Other Organs: A Review of Techniques and Applications
Current Molecular Imaging (Discontinued) Molecular Targeting of Protein Kinases to Optimize Selectivity and Resistance Profiles of Kinase Inhibitors
Current Topics in Medicinal Chemistry Triiodothyronine (T3) Effects on Cardiovascular System in Patients with Heart Failure
Recent Patents on Cardiovascular Drug Discovery Monoclonal Antibodies in Cancer Therapy
Current Medicinal Chemistry - Anti-Cancer Agents Dendrimers and Dendritic Polymers as Anti-infective Agents: New Antimicrobial Strategies for Therapeutic Drugs
Anti-Infective Agents in Medicinal Chemistry The Yin and Yang of BK Channels in Epilepsy
CNS & Neurological Disorders - Drug Targets Physical Characterization and <i>In Vitro</i> Evaluation of Dissolution Rate from Cefpodoxime Proxetil Loaded Self Solidifying Solid SNEDDS
Current Drug Delivery Editorial(Thematic Issue: Hypertension and Diabetes – Update in 2013)
Current Hypertension Reviews Recent Updates on Current and Upcoming Biomarkers for Cardiovascular Diseases
Current Pharmaceutical Design Bioanalytical Systems Based on Bioluminescence Resonance Energy Transfer Using Firefly Luciferase
Combinatorial Chemistry & High Throughput Screening Current Updates on Therapeutic Advances in the Management of Cardiovascular Diseases
Current Pharmaceutical Design New Strategies for Necrotizing Enterocolitis Diagnosis and Prevention in Newborns
Current Pediatric Reviews Early Life Stress in Depressive Patients: Role of Glucocorticoid and Mineralocorticoid Receptors and of Hypothalamic-Pituitary-Adrenal Axis Activity
Current Pharmaceutical Design CCL2-CCR2 Signaling in Disease Pathogenesis
Endocrine, Metabolic & Immune Disorders - Drug Targets Antihyperglycemic Activity and Safety Assessment of the Aqueous Extract of Aerial Parts of Scorzonera undulata ssp deliciosa in Rat
Cardiovascular & Hematological Disorders-Drug Targets HLA-G Expression in Cancers: Potential Role in Diagnosis, Prognosis and Therapy
Endocrine, Metabolic & Immune Disorders - Drug Targets Potential Role of Rho-Associated Protein Kinase Inhibitors for Glaucoma Treatment
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery