Microwave and Conventional Method Assisted Synthesis of 2-(substituted) -3-(4-methoxybenzyl) Thiazolidin-4-ones Using ZrOCl2·8H2O as a Catalyst

Author(s): Aniket P. Sarkate*, Dattatraya N. Pansare, Ishwari A. Kale, Devanand B. Shinde.

Journal Name: Current Microwave Chemistry

Volume 4 , Issue 2 , 2017

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Graphical Abstract:


Background: Although several methods are reported for the synthesis of thiazolidin-4-ones analogues, the microwave assisted method reported in this work is simple and proceeds with high yields in short time.

Methods: In the synthetic method, the targeted thiazolidin-4-ones were synthesized with the help of the microwave by reacting aldehydes, benzyl amine and thioglycolic acid in the presence of zirconium oxychloride and ethanol.

Results: All the thiazolidin-4-ones were obtained in good yield (95%-98%) with the help of a microwave technique (6-8 min), in less time as compared to the conventional method (2-4 h).

Conclusion: Microwave assisted synthesis will be a useful alternative method for the synthesis of diverse range of thiazolidin-4-ones.

Keywords: Aromatic aldehydes, microwave irradiation, ZrOCl2·8H2O.

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Article Details

Year: 2017
Page: [139 - 145]
Pages: 7
DOI: 10.2174/2213335603666160922115342
Price: $58

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