Background: Although several methods are reported for the synthesis of thiazolidin-4-ones
analogues, the microwave assisted method reported in this work is simple and proceeds with high
yields in short time.
Methods: In the synthetic method, the targeted thiazolidin-4-ones were synthesized with the help of
the microwave by reacting aldehydes, benzyl amine and thioglycolic acid in the presence of
zirconium oxychloride and ethanol.
Results: All the thiazolidin-4-ones were obtained in good yield (95%-98%) with the help of a microwave
technique (6-8 min), in less time as compared to the conventional method (2-4 h).
Conclusion: Microwave assisted synthesis will be a useful alternative method for the synthesis of diverse
range of thiazolidin-4-ones.