Abstract
Despite being widely used for cancer treatment, conventional chemotherapeutic regimens based on anti-cancer drugs possess significant drawbacks in discriminating between normal and cancer cells, leading to detrimental effects on healthy tissues. The development of nano-formulations encapsulating the chemotherapy drugs is highly expected to improve the anti-cancer activities with favorable pharmacokinetic profile and consequentially minimized side-effects. Several organic and inorganic nanoparticles have received tremendous attention as carriers of various anticancer drugs in pre-clinical and clinical settings. In this review, we discuss on the progress of formulating and investigating various nano-formulationsin treating different cancers, with an emphasis on in vivo studies utilizing the nanoparticles for carrying small molecular weight anti-cancer drugs and focusing on the biocompatibility, targeting capability, cellular uptake, and the tumor regression efficacy of those nano-formulations.
Keywords: Cancer, multi-functional nanoparticle, anti-cancer drug, active targeting, passive targeting, EPR effect, controlled release.
Current Cancer Therapy Reviews
Title:Systemic Delivery of Nanoformulations of Anti-cancer Drugs with Therapeutic Potency in Animal Models of Cancer
Volume: 12 Issue: 3
Author(s): Md. Emranul Karim, Rozita Rosli and Ezharul H. Chowdhury
Affiliation:
Keywords: Cancer, multi-functional nanoparticle, anti-cancer drug, active targeting, passive targeting, EPR effect, controlled release.
Abstract: Despite being widely used for cancer treatment, conventional chemotherapeutic regimens based on anti-cancer drugs possess significant drawbacks in discriminating between normal and cancer cells, leading to detrimental effects on healthy tissues. The development of nano-formulations encapsulating the chemotherapy drugs is highly expected to improve the anti-cancer activities with favorable pharmacokinetic profile and consequentially minimized side-effects. Several organic and inorganic nanoparticles have received tremendous attention as carriers of various anticancer drugs in pre-clinical and clinical settings. In this review, we discuss on the progress of formulating and investigating various nano-formulationsin treating different cancers, with an emphasis on in vivo studies utilizing the nanoparticles for carrying small molecular weight anti-cancer drugs and focusing on the biocompatibility, targeting capability, cellular uptake, and the tumor regression efficacy of those nano-formulations.
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Karim Emranul Md., Rosli Rozita and Chowdhury H. Ezharul, Systemic Delivery of Nanoformulations of Anti-cancer Drugs with Therapeutic Potency in Animal Models of Cancer, Current Cancer Therapy Reviews 2016; 12 (3) . https://dx.doi.org/10.2174/1573394712666160919101827
DOI https://dx.doi.org/10.2174/1573394712666160919101827 |
Print ISSN 1573-3947 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6301 |
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Current progress in Protein Degradation and Cancer Therapy
argeted Protein Degradation is gaining momentum in cancer therapy, it facilitate targeting undruggable proteins, it overcome cancer resistance and avoid undesirable side effects. Thus small molecules degraders have emerged as novel therapeutic strategy. Targeted protein degradation (TPD), the process of eliminating a protein of interest hold a great promise for ...read more
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