Abstract
The need for the improvement of vaccine potency as well as reducing toxicity in healthy recipients has motivated studies of the formulation of vaccines regarding control of how, when, and where antigens and adjuvants encounter immune cells and other cells/tissues following vaccine administration. Immunostimulatory complexes (ISCOMs) and ISCOMATRIXTM adjuvants are versatile and flexible systems with various phospholipids and saponin components. They are being used in novel vaccines for either infectious diseases or cancer. This article presents a brief review of the latest developments using such adjuvants and possible new applications.
Keywords: ISCOMs, ISCOMATRIX™, vaccine, adjuvant, safety, immunogenicity, immune response, innate immune response, adaptive immune response.
Current Pharmaceutical Design
Title:An Updated Review of ISCOMSTM and ISCOMATRIXTM Vaccines
Volume: 22 Issue: 41
Author(s): Alexis Garcia and Diego Lema
Affiliation:
Keywords: ISCOMs, ISCOMATRIX™, vaccine, adjuvant, safety, immunogenicity, immune response, innate immune response, adaptive immune response.
Abstract: The need for the improvement of vaccine potency as well as reducing toxicity in healthy recipients has motivated studies of the formulation of vaccines regarding control of how, when, and where antigens and adjuvants encounter immune cells and other cells/tissues following vaccine administration. Immunostimulatory complexes (ISCOMs) and ISCOMATRIXTM adjuvants are versatile and flexible systems with various phospholipids and saponin components. They are being used in novel vaccines for either infectious diseases or cancer. This article presents a brief review of the latest developments using such adjuvants and possible new applications.
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Cite this article as:
Garcia Alexis and Lema Diego, An Updated Review of ISCOMSTM and ISCOMATRIXTM Vaccines, Current Pharmaceutical Design 2016; 22 (41) . https://dx.doi.org/10.2174/1381612822666160915161302
DOI https://dx.doi.org/10.2174/1381612822666160915161302 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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