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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Review Article

An Updated Review of ISCOMSTM and ISCOMATRIXTM Vaccines

Author(s): Alexis Garcia and Diego Lema

Volume 22, Issue 41, 2016

Page: [6294 - 6299] Pages: 6

DOI: 10.2174/1381612822666160915161302

Price: $65

Abstract

The need for the improvement of vaccine potency as well as reducing toxicity in healthy recipients has motivated studies of the formulation of vaccines regarding control of how, when, and where antigens and adjuvants encounter immune cells and other cells/tissues following vaccine administration. Immunostimulatory complexes (ISCOMs) and ISCOMATRIXTM adjuvants are versatile and flexible systems with various phospholipids and saponin components. They are being used in novel vaccines for either infectious diseases or cancer. This article presents a brief review of the latest developments using such adjuvants and possible new applications.

Keywords: ISCOMs, ISCOMATRIX™, vaccine, adjuvant, safety, immunogenicity, immune response, innate immune response, adaptive immune response.


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