Second Generation Proteasome Inhibitors in Multiple Myeloma

Author(s): Alessandro Gozzetti*, Giulia Papini, Veronica Candi, Corrado Zuanelli Brambilla, Santina Sirianni, Monica Bocchia.

Journal Name: Anti-Cancer Agents in Medicinal Chemistry

Volume 17 , Issue 7 , 2017

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Abstract:

Bortezomib was the first proteasome inhibitor (PI) discovered and demonstrated great efficacy in myeloma, both in vitro and in patients. However, still many patients ultimately relapse and there is the need for novel therapies. A second generation of PI have been discovered, potentially more effective ands some also orally administered. Carfilzomib is an irreversible proteasome inhibitor that showed great efficacy in clinical studies. Ixazomib is an oral compound that has been introduced recently in the therapeutic spectrum. Novel agents such as Marizomib seem promising in the fact that can also pass through the blood brain barrier and maybe effective also in CNS muyeloma. This review focus on all proteasome inhibitors available in clinics and the new ones coming soon.

Keywords: Myeloma, bortezomib, new proteasome inhibitors, carfilzomib, oprozomib.

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Article Details

VOLUME: 17
ISSUE: 7
Year: 2017
Page: [920 - 926]
Pages: 7
DOI: 10.2174/1871520616666160902101622
Price: $58

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