Pharmacological Functional MRI in Rodent Model

Tomokazu      Tsurugizawa

Abstract

The pharmacological effects on the brain will occur widely in whole brain. Therefore, pharmacological functional MRI (fMRI) is a promising non-invasive tool to investigate the whole brain activation following pharmacological stimulation. The multimodal fMRI techniques, which reflect the vascular response (blood oxygenation level dependent fMRI), neuron/astrocyte activity (diffusion fMRI) and Ca2+ influx in excitatory neurons (manganese enhanced MRI), enable to observe the neuronal activation in rodent model. In the present study, the multimodal pharmacological fMRI method in rodents will be introduced.

Keywords: Functional MRI, rodent, anesthesia, BOLD, DfMRI, MEMRI, pharmacological fMRI.

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Current Psychopharmacology

Title:Pharmacological Functional MRI in Rodent Model

Volume: 6

Author(s): Tomokazu Tsurugizawa*

Affiliation:

Neurospin, Commissariat a l`Energie Atomique et aux Energies Alternatives, Gif-sur- Yvette,France

Keywords: Functional MRI, rodent, anesthesia, BOLD, DfMRI, MEMRI, pharmacological fMRI.

Abstract: The pharmacological effects on the brain will occur widely in whole brain. Therefore, pharmacological functional MRI (fMRI) is a promising non-invasive tool to investigate the whole brain activation following pharmacological stimulation. The multimodal fMRI techniques, which reflect the vascular response (blood oxygenation level dependent fMRI), neuron/astrocyte activity (diffusion fMRI) and Ca2+ influx in excitatory neurons (manganese enhanced MRI), enable to observe the neuronal activation in rodent model. In the present study, the multimodal pharmacological fMRI method in rodents will be introduced.

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Tsurugizawa Tomokazu*, Pharmacological Functional MRI in Rodent Model, Current Psychopharmacology 2017; 6 (1) . https://dx.doi.org/10.2174/2211556005666160901150718

DOI https://dx.doi.org/10.2174/2211556005666160901150718	Print ISSN 2211-5560
Publisher Name Bentham Science Publisher	Online ISSN 2211-5579

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