Abstract
Therapeutic proteins are engineered proteins produced in the laboratory for pharmaceutical use. With the advent of recombinant DNA technology, the proteins can be generated in specific host cells under defined conditions. In the process of production of genetically engineered animals, the gene of interest can be added at a single cell stage to produce a cloned animal from genetically engineered cells. Several recombinant cytokines, clotting factors etc have been licensed and are currently being utilized for the treatment of cancer, infectious diseases, hemophilia, anemia, multiple sclerosis, and hepatitis B/C. Therapeutic proteins that are useful for human are successfully produced in poultry as well as in livestock animals. However, the fastest growing class of therapeutic proteins are antibodies especially monoclonal antibodies (mAb), the most important class of therapeutic protein with the potential to generate significant revolution in terms of clinical success rate. Here, we review the most recent clinical advances in the field of emerging and existing therapeutic proteins.
Keywords: Chimeric antibodies, clotting factors, cytokines, hormones, medicinal chemistry, therapeutic proteins.
Current Protein & Peptide Science
Title:Recent Updates on Molecular Genetic Engineering Approaches and Applications of Human Therapeutic Proteins
Volume: 18 Issue: 3
Author(s): Asim Azhar, Ejaj Ahmad, Qamar Zia, Mohammad Owais and Ghulam Md Ashraf
Affiliation:
Keywords: Chimeric antibodies, clotting factors, cytokines, hormones, medicinal chemistry, therapeutic proteins.
Abstract: Therapeutic proteins are engineered proteins produced in the laboratory for pharmaceutical use. With the advent of recombinant DNA technology, the proteins can be generated in specific host cells under defined conditions. In the process of production of genetically engineered animals, the gene of interest can be added at a single cell stage to produce a cloned animal from genetically engineered cells. Several recombinant cytokines, clotting factors etc have been licensed and are currently being utilized for the treatment of cancer, infectious diseases, hemophilia, anemia, multiple sclerosis, and hepatitis B/C. Therapeutic proteins that are useful for human are successfully produced in poultry as well as in livestock animals. However, the fastest growing class of therapeutic proteins are antibodies especially monoclonal antibodies (mAb), the most important class of therapeutic protein with the potential to generate significant revolution in terms of clinical success rate. Here, we review the most recent clinical advances in the field of emerging and existing therapeutic proteins.
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Cite this article as:
Azhar Asim, Ahmad Ejaj, Zia Qamar, Owais Mohammad and Ashraf Md Ghulam, Recent Updates on Molecular Genetic Engineering Approaches and Applications of Human Therapeutic Proteins, Current Protein & Peptide Science 2017; 18 (3) . https://dx.doi.org/10.2174/1389203717666160901114911
DOI https://dx.doi.org/10.2174/1389203717666160901114911 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
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