Abstract
Diabetes Mellitus (DM) is a metabolic disease characterized by high blood sugar levels. Recently, it has emerged as an important and global health problem with long-term complications and high economic burden. α-Amylase (α-Amy) and α-glucosidase (α-Gls) are two enzymes which are involved in the hydrolysis of starch into sugars and disaccharides leading to the increase of blood glucose level. Hence, inhibition of α-amylase and α-glucosidase plays key role in the treatment of type 2 diabetes. Heterocyclic compounds -both synthetic and naturally occurring derivatives- possess efficient biological properties. At this juncture, they have demonstrated potent inhibitory activity against α-Amy and α-Gls and were found to be versatile tools for the development of novel anti-diabetic agents.
Keywords: α-Amylase, α-Glucosidase, Diabetes, Heterocycles, Synthesis, Natural Products.
Current Topics in Medicinal Chemistry
Title:Heterocyclic Compounds: Effective α-Amylase and α-Glucosidase Inhibitors
Volume: 17 Issue: 4
Author(s): Mina Saeedi, Abbas Hadjiakhondi, Seyed Mohammad Nabavi and Azadeh Manayi
Affiliation:
Keywords: α-Amylase, α-Glucosidase, Diabetes, Heterocycles, Synthesis, Natural Products.
Abstract: Diabetes Mellitus (DM) is a metabolic disease characterized by high blood sugar levels. Recently, it has emerged as an important and global health problem with long-term complications and high economic burden. α-Amylase (α-Amy) and α-glucosidase (α-Gls) are two enzymes which are involved in the hydrolysis of starch into sugars and disaccharides leading to the increase of blood glucose level. Hence, inhibition of α-amylase and α-glucosidase plays key role in the treatment of type 2 diabetes. Heterocyclic compounds -both synthetic and naturally occurring derivatives- possess efficient biological properties. At this juncture, they have demonstrated potent inhibitory activity against α-Amy and α-Gls and were found to be versatile tools for the development of novel anti-diabetic agents.
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Cite this article as:
Saeedi Mina, Hadjiakhondi Abbas, Nabavi Mohammad Seyed and Manayi Azadeh, Heterocyclic Compounds: Effective α-Amylase and α-Glucosidase Inhibitors, Current Topics in Medicinal Chemistry 2017; 17 (4) . https://dx.doi.org/10.2174/1568026616666160824104655
DOI https://dx.doi.org/10.2174/1568026616666160824104655 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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