Abstract
Background: Glioblastoma multiforme (GBM) is the most frequent brain tumor. Despite recent advances in treatment approaches the prognosis remains poor, with a median overall survival of 14.6 months. Immunotherapy is the subject of ongoing research and its benefit is becoming evident in other malignancies. Immune check-points such as cytotoxic T lymphocyte associated antigen 4 (CTLA-4), programmed cell death receptor (PD-1) and indoleamine 2,3-dioxygenase (IDO) reduce immune response.
Objective: To clarify the role of immune check point inhibitors in GBM management. Methods: Preclinical and clinical trials of immune check-point inhibitors in GBM were obtained by searching for English peer-reviewed articles on PubMed databases, trials registered on clincaltrials. gov and abstracts recently presented at international congresses. Results: Immune check point inhibitors may be of critical importance for the design of future immunotherapy approaches in GBM management. Conclusion: Immune check-point inhibitors should be considered a promising treatment option in GBM.Keywords: Immunotherapy, glioblastoma multiforme, check-point, radiotherapy, PD-1, CTLA-4, ipilimumab, immune system.
Current Cancer Drug Targets
Title:New Approaches in Glioblastoma Multiforme: The Potential Role of Immune- check Point Inhibitors
Volume: 17 Issue: 3
Author(s): Francesca De Felice, Daniela Musio, Raffaele Cassese, Giovanni Luca Gravina and Vincenzo Tombolini
Affiliation:
Keywords: Immunotherapy, glioblastoma multiforme, check-point, radiotherapy, PD-1, CTLA-4, ipilimumab, immune system.
Abstract: Background: Glioblastoma multiforme (GBM) is the most frequent brain tumor. Despite recent advances in treatment approaches the prognosis remains poor, with a median overall survival of 14.6 months. Immunotherapy is the subject of ongoing research and its benefit is becoming evident in other malignancies. Immune check-points such as cytotoxic T lymphocyte associated antigen 4 (CTLA-4), programmed cell death receptor (PD-1) and indoleamine 2,3-dioxygenase (IDO) reduce immune response.
Objective: To clarify the role of immune check point inhibitors in GBM management. Methods: Preclinical and clinical trials of immune check-point inhibitors in GBM were obtained by searching for English peer-reviewed articles on PubMed databases, trials registered on clincaltrials. gov and abstracts recently presented at international congresses. Results: Immune check point inhibitors may be of critical importance for the design of future immunotherapy approaches in GBM management. Conclusion: Immune check-point inhibitors should be considered a promising treatment option in GBM.Export Options
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Cite this article as:
Felice De Francesca, Musio Daniela, Cassese Raffaele, Gravina Luca Giovanni and Tombolini Vincenzo, New Approaches in Glioblastoma Multiforme: The Potential Role of Immune- check Point Inhibitors, Current Cancer Drug Targets 2017; 17 (3) . https://dx.doi.org/10.2174/1568009616666160813183738
DOI https://dx.doi.org/10.2174/1568009616666160813183738 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
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