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Current Pharmacogenomics and Personalized Medicine

Editor-in-Chief

ISSN (Print): 1875-6921
ISSN (Online): 1875-6913

Research Article

Allele Frequencies of CYP2D6, CYP3A5 and DPYD Genes Polymorphisms in the Healthy Yakut Population

Author(s): Filipp F. Vasilyev, Diana A. Danilova, Vladimir S. Kaimonov, Yana V. Chertovskih and Nadezda R. Maksimova

Volume 14, Issue 1, 2016

Page: [50 - 55] Pages: 6

DOI: 10.2174/1875692114666160801151257

Price: $65

Abstract

Background: It is known that the distribution of polymorphism frequencies can vary greatly between different ethnic groups, resulting in variable percentages of poor, intermediate or extensive metabolizers in a given population.

Objective: This study was carried out to estimate the genotype frequencies of common variants in the CYP2D6, CYP3A5 and DPYD genes in the Yakut population from North-Eastern Siberia. To compare the allelic distribution found with the frequencies reported for other ethnic groups.

Method: Genotyping was carried out by real-time polymerase-chain reaction in a total of 100 healthy unrelated Yakut subjects (CYP2D6 c.100C>T, CYP3A5 g.6986G>A, DPYD c.1905+1G>A, DPYD c.1679T>G, DPYD c.2846T>A).

Results: The allele frequencies for CYP3A5*3 and DPYD*13 in Yakuts were 0.08 and 0.01, respectively. No DPYD*2A and DPYD c.2846A alleles were detected.

Conclusion: Our data on the distribution of frequencies of genotypes and alleles of polymorphisms of CYP2D6, CYP3A5 and DPYD genes in the Yakut population as a whole are more characteristic of the European populations.

Keywords: Allele frequency, genotyping, personalize medicine, pharmacogenetics, polymorphism, Yakuts.

Graphical Abstract

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