Abstract
Narcolepsy is an incurable neurological disorder when the brain is not able to regulate a sleep and wakefulness cycle correctly. The affected person suddenly falls asleep during the day or he/she suffers from excessive day sleepiness. In addition, people may also suffer from cataplexy, hypnagogic hallucinations, sleep paralysis, and disturbed nighttime sleep.
The purpose of this review study is to provide the latest information on both clinical and socioeconomic issues in the field of narcolepsy treatment and emphasize its benefits and limitations.
The methodological approaches include a method of literature review of available sources exploring the issue of narcolepsy, both from a global and specific perspective point of view. On the basis of evaluation of these literature sources, the researched issue is examined.
The main benefits (e.g., new drugs are being tested or non-invasive cognitive behavioral therapies are being applied) and limitations (e.g., late diagnosis of the disease or lifelong and costly treatment) of the treatment of narcolepsy are highlighted.
The findings call for more research in the field of the development of novel drugs reflecting understanding of the neurological basis of narcolepsy and early diagnosis in order to eliminate the symptoms of narcolepsy and prevent the development of this disease.
Keywords: Causes, diagnosis, narcolepsy, prevalence, symptoms, treatment.
Mini-Reviews in Medicinal Chemistry
Title:A Global View on Narcolepsy - A Review Study
Volume: 18 Issue: 5
Author(s): Blanka Klimova, Petra Maresova, Michal Novotny and Kamil Kuca*
Affiliation:
- Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove,Czech Republic
Keywords: Causes, diagnosis, narcolepsy, prevalence, symptoms, treatment.
Abstract: Narcolepsy is an incurable neurological disorder when the brain is not able to regulate a sleep and wakefulness cycle correctly. The affected person suddenly falls asleep during the day or he/she suffers from excessive day sleepiness. In addition, people may also suffer from cataplexy, hypnagogic hallucinations, sleep paralysis, and disturbed nighttime sleep.
The purpose of this review study is to provide the latest information on both clinical and socioeconomic issues in the field of narcolepsy treatment and emphasize its benefits and limitations.
The methodological approaches include a method of literature review of available sources exploring the issue of narcolepsy, both from a global and specific perspective point of view. On the basis of evaluation of these literature sources, the researched issue is examined.
The main benefits (e.g., new drugs are being tested or non-invasive cognitive behavioral therapies are being applied) and limitations (e.g., late diagnosis of the disease or lifelong and costly treatment) of the treatment of narcolepsy are highlighted.
The findings call for more research in the field of the development of novel drugs reflecting understanding of the neurological basis of narcolepsy and early diagnosis in order to eliminate the symptoms of narcolepsy and prevent the development of this disease.
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Cite this article as:
Klimova Blanka, Maresova Petra, Novotny Michal and Kuca Kamil*, A Global View on Narcolepsy - A Review Study, Mini-Reviews in Medicinal Chemistry 2018; 18 (5) . https://dx.doi.org/10.2174/1389557516666160801095630
DOI https://dx.doi.org/10.2174/1389557516666160801095630 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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