Abstract
Cancer cells evade apoptosis, which is regulated by proteins of Bcl-2 family in the intrinsic pathways. Numerous experimental three-dimensional (3D) structures of the apoptotic proteins and the proteins bound with small chemical molecules/peptides/proteins have been reported in the literature. In this review article, the 3D structures of the Bcl-2 family proteins from Homo sapiens and as well complex structures of the anti-apoptotic proteins bound with small molecular inhibitors reported in the literature to date have been comprehensively listed out and described in detail. Moreover, the molecular mechanisms by which the Bcl-2 family proteins modulate the apoptotic processes and strategies for designing antagonists to anti-apoptotic proteins have been concisely discussed.
Keywords: Apoptosis, Bcl-2 family proteins, anti-cancer compounds and structure-function relationships.
Protein & Peptide Letters
Title:A Review on Structures and Functions of Bcl-2 Family Proteins from Homo sapiens
Volume: 23 Issue: 10
Author(s): Dakshinamurthy Sivakumar and Thirunavukkarasu Sivaraman
Affiliation:
Keywords: Apoptosis, Bcl-2 family proteins, anti-cancer compounds and structure-function relationships.
Abstract: Cancer cells evade apoptosis, which is regulated by proteins of Bcl-2 family in the intrinsic pathways. Numerous experimental three-dimensional (3D) structures of the apoptotic proteins and the proteins bound with small chemical molecules/peptides/proteins have been reported in the literature. In this review article, the 3D structures of the Bcl-2 family proteins from Homo sapiens and as well complex structures of the anti-apoptotic proteins bound with small molecular inhibitors reported in the literature to date have been comprehensively listed out and described in detail. Moreover, the molecular mechanisms by which the Bcl-2 family proteins modulate the apoptotic processes and strategies for designing antagonists to anti-apoptotic proteins have been concisely discussed.
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Cite this article as:
Sivakumar Dakshinamurthy and Sivaraman Thirunavukkarasu, A Review on Structures and Functions of Bcl-2 Family Proteins from Homo sapiens, Protein & Peptide Letters 2016; 23 (10) . https://dx.doi.org/10.2174/0929866523666160719094636
DOI https://dx.doi.org/10.2174/0929866523666160719094636 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
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