Abstract
Protein aggregation and amyloidogenesis are closely associated with the pathogenesis of neurodegenerative diseases. Elucidating the morphology and structure of the amyloid aggregates or fibrils is important for understanding the molecular mechanisms of these proteinopathies. This review article describes the general principle and establishment of solid-state circular dichroism (ssCD) spectroscopy, and discusses its application for the analysis of secondary structures of proteins or peptides in amyloids and structural transformation of these proteins or peptides during their amyloidogenic aggregation.
Keywords: Circular dichroism, Solid state, Protein amyloid, Secondary structure, Structural transformation.
Current Protein & Peptide Science
Title:Study of Protein Amyloid-Like Aggregates by Solid-State Circular Dichroism Spectroscopy
Volume: 18 Issue: 1
Author(s): Hong-Yu Hu, Lei-Lei Jiang and Jun-Ye Hong
Affiliation:
Keywords: Circular dichroism, Solid state, Protein amyloid, Secondary structure, Structural transformation.
Abstract: Protein aggregation and amyloidogenesis are closely associated with the pathogenesis of neurodegenerative diseases. Elucidating the morphology and structure of the amyloid aggregates or fibrils is important for understanding the molecular mechanisms of these proteinopathies. This review article describes the general principle and establishment of solid-state circular dichroism (ssCD) spectroscopy, and discusses its application for the analysis of secondary structures of proteins or peptides in amyloids and structural transformation of these proteins or peptides during their amyloidogenic aggregation.
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Cite this article as:
Hu Hong-Yu, Jiang Lei-Lei and Hong Jun-Ye, Study of Protein Amyloid-Like Aggregates by Solid-State Circular Dichroism Spectroscopy, Current Protein & Peptide Science 2017; 18 (1) . https://dx.doi.org/10.2174/1389203717666160709185323
DOI https://dx.doi.org/10.2174/1389203717666160709185323 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
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