Abstract
Objective: The spirooxindole heterocyclic scaffold is found in many natural products and has been identified as an important bioactive agent.
Background: Over the past few decades, various spirooxindole-containing compounds have been reported to possess biological properties and hence found in the structure of many synthetic pharmaceuticals.
This mini-review describes the most promising examples of this class of compounds possessing biological activity including anticancer, anti-inflammatory, and antimicrobial activities.
Conclusion: The current review focuses on the biological activity of compounds containing the spirooxindole scaffold.
Keywords: Biological importance, chemistry, heterocycles, pharmacophores, spirooxindoles, synthesis.
Mini-Reviews in Medicinal Chemistry
Title:Spirooxindoles as Potential Pharmacophores
Volume: 17 Issue: 16
Author(s): Siva S. Panda*, Rachel A. Jones, Praveen Bachawala and Prabhu P. Mohapatra
Affiliation:
- Department of Chemistry & Physics, Augusta University, Augusta, GA 30912,United States
Keywords: Biological importance, chemistry, heterocycles, pharmacophores, spirooxindoles, synthesis.
Abstract: Objective: The spirooxindole heterocyclic scaffold is found in many natural products and has been identified as an important bioactive agent.
Background: Over the past few decades, various spirooxindole-containing compounds have been reported to possess biological properties and hence found in the structure of many synthetic pharmaceuticals.
This mini-review describes the most promising examples of this class of compounds possessing biological activity including anticancer, anti-inflammatory, and antimicrobial activities.
Conclusion: The current review focuses on the biological activity of compounds containing the spirooxindole scaffold.
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Cite this article as:
Panda S. Siva *, Jones A. Rachel , Bachawala Praveen and Mohapatra P. Prabhu , Spirooxindoles as Potential Pharmacophores, Mini-Reviews in Medicinal Chemistry 2017; 17 (16) . https://dx.doi.org/10.2174/1389557516666160624125108
DOI https://dx.doi.org/10.2174/1389557516666160624125108 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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