Abstract
The labeling of biomolecule using 99mTc-tricarbonyl is an interesting tool for the diagnosis of diseases. This labeling startegy has several advantages as compared to other common radiolabeling techniques. This review is a complete overview of synthesis and chemistry of 99mTc-tricarbonyl molecule for labeling peptides and proteins. Also, the effect of ligand type on the stability and in vivo biodistribution of 99mTc-tricarbonyl labeled biomolecules are discussed. Chemistries of cyclopentadienyl and hexa histidine tag as two important bifunctional chelating agents (BFCA) are presented. The in vitro and in vivo behaviors of some 99mTc-tricarbonyl labeled peptides and proteins are explained. Preclinical outcomes revealed that these labeled compounds are biologically, kinetically and thermodynamically stable. Findings showed that 99mTc-tricarbonyl labeled biomolecules are promising tools for future clinical applications in image diagnosis.
Keywords: Tricarbonyl, 99mTc, peptide, labeling.
Current Pharmaceutical Design
Title:The Past, Current Studies and Future of Organometallic 99mTc(CO)3 Labeled Peptides and Proteins
Volume: 22 Issue: 31
Author(s): Majid Piramoon and Seyed Jalal Hosseinimehr
Affiliation:
Keywords: Tricarbonyl, 99mTc, peptide, labeling.
Abstract: The labeling of biomolecule using 99mTc-tricarbonyl is an interesting tool for the diagnosis of diseases. This labeling startegy has several advantages as compared to other common radiolabeling techniques. This review is a complete overview of synthesis and chemistry of 99mTc-tricarbonyl molecule for labeling peptides and proteins. Also, the effect of ligand type on the stability and in vivo biodistribution of 99mTc-tricarbonyl labeled biomolecules are discussed. Chemistries of cyclopentadienyl and hexa histidine tag as two important bifunctional chelating agents (BFCA) are presented. The in vitro and in vivo behaviors of some 99mTc-tricarbonyl labeled peptides and proteins are explained. Preclinical outcomes revealed that these labeled compounds are biologically, kinetically and thermodynamically stable. Findings showed that 99mTc-tricarbonyl labeled biomolecules are promising tools for future clinical applications in image diagnosis.
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Cite this article as:
Piramoon Majid and Hosseinimehr Jalal Seyed, The Past, Current Studies and Future of Organometallic 99mTc(CO)3 Labeled Peptides and Proteins, Current Pharmaceutical Design 2016; 22 (31) . https://dx.doi.org/10.2174/1381612822666160623081838
DOI https://dx.doi.org/10.2174/1381612822666160623081838 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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