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Current Cancer Drug Targets

Editor-in-Chief

ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

Review Article

Urotensin-II Receptor: A Double Identity Receptor Involved in Vasoconstriction and in the Development of Digestive Tract Cancers and other Tumors

Author(s): Alessandro Federico, Silvia Zappavigna, Marcello Dallio, Gabriella Misso, Francesco Merlino, Carmela Loguercio, Ettore Novellino, Paolo Grieco and Michele Caraglia

Volume 17, Issue 2, 2017

Page: [109 - 121] Pages: 13

DOI: 10.2174/1568009616666160621101248

Price: $65

Abstract

Urotensin II and Urotensin-II receptors are important molecular factors that regulate vasoconstriction and all the diseases that are linked to abnormalities in blood pressure regulation (i.e.: hypertension, kidney diseases, cirrhosis etc.). Recently, Urotensin II and its receptor have also been involved in metabolic syndrome, diabetes and schizophrenia. Recent strong findings suggest that Urotensin II and its receptor are involved in the onset and development of different epithelial cancers. Indeed, it was reported that cell growth, motility and invasion in human breast, bladder, prostate, colorectal and glioblastoma cancer cells were regulated by Urotensin II and Urotensin-II receptor axis. This axis also regulated focal adhesion kinase and small Guanosine-5'-triphosphate binding proteins that likely had a role in motility and invasion mediated by Urotensin-II receptor. Additionally, its expression on tumour tissues is variably associated to the prediction of the clinical outcome of the patients and it can be considered an alternative molecular marker to be used as prognostic factor in human cancers. In conclusion, a new weapon in the treatment of human cancers is highlighting a new scenario for the future.

Keywords: Urotensin-II receptors, digestive tract cancers, cancer prognostic marker.

Graphical Abstract
[1]
Douglas, S.A.; Ohlstein, E.H. Human urotensin-II, the most potent mammalian vasoconstrictor identified to date, as a therapeutic target for the management of cardivascular diseases. Trends Cardiovasc. Med., 2000, 10, 229-237.
[2]
Grieco, P.; Rovero, P.; Novellino, E. Recent Structure Activity Studies of the Peptide Hormone Urotensin-II: A Potent Vaso-constrictor. Curr. Med. Chem., 2003, 10, 1241-1253.
[3]
Pearson, D.; Shively, J.E.; Clark, B.R.; Geschwind, I.I.; Barkley, M.; Nishioka, R.S.; Bern, H.A. Urotensin II: a somatostain-like peptide in the caudal neurosecretory system of fishes. Proc. Natl. Acad. Sci. USA, 1980, 77, 5021-5024.
[4]
Davenport, A.P.; Maguire, J.J.; Urotensin, I.I. Fish neuropeptide catches orphan receptor. Trends Pharmacol. Sci., 2000, 21, 80-82.
[5]
Marchese, A.; Heiber, M.; Nguyen, T.; Heng, H.H.; Saldivia, V.R.; Cheng, R.; Murphy, P.M.; Tsui, L.C.; Shi, X.; Gregor, P.; George, S.R.; O’Dowd, B.F.; Docherty, J.M. Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors. Genomics, 1995, 29, 335-344.
[6]
Douglas, S.A.; Ashton, D.J.; Sauermelch, C.F.; Coatney, R.W.; Ohlstein, D.H.; Ruffolo, M.R.; Ohlstein, E.H.; Aiyar, N.V.; Willette, R.N. Human urotensin-II is a potent vasoactive peptide: pharmacological characterization in the rat, mouse, dog and primate. J. Cardiovasc. Pharmacol., 2000, 36(5)(Suppl. 1), S163-S166.
[7]
Mc Master, D.; Kobayashi, Y.; Rivier, J.; Lederis, K. Characterization of the biologically and antigenically important regions of urotensin II. Proc. West. Pharmacol. Soc., 1986, 29, 205-208.
[8]
Chatenet, D.; Dubessy, C.; Leprince, J.; Boularan, C.; Carlier, L.; Ségalas-Milazzo, I.; Guilhaudis, L.; Oulyadi, H.; Davoust, D.; Scalbert, E.; Pfeiffer, B.; Renard, P.; Tonon, M.C.; Lihrmann, I.; Pacaud, P.; Vaudry, H. Structure-activity relationships and structural conformation of a novel urotensin II-related peptide. Peptide, 2004, 25, 1819-1830.
[9]
Nothacker, H.P.; Wang, Z.; McNeill, A.M.; Saito, Y.; Merten, S.; O’Dowd, B.; Duckles, S.P.; Civelli, O. Identification of the natural liogand of an orphan G- protein coupled receptor involved in the regulation of vasoconstriction. Nat. Cell Biol., 1999, 1, 383-385.
[10]
Mori, M.; Sugo, T.; Abe, M.; Shimomura, Y.; Kurihara, M.; Kitada, C.; Kikuchi, K.; Shintani, Y.; Kurokawa, T.; Onda, H.; Nishimura, O.; Fujino, M. Urotensin II is the endogenous ligand of a G-protein coupled orphan receptor, SENR (GPR14). Biochem. Biophys. Res. Commun., 1999, 265, 123-129.
[11]
Liu, Q.; Pong, S.S.; Zeng, Z.; Zhang, Q.; Howard, A.D.; Williams, D.L., Jr; Davidoff, M.; Wang, R.; Austin, C.P.; McDonald, T.P.; Bai, C.; George, S.R.; Evans, J.F.; Caskey, C.T. Identification of urotensin II as the endogenous ligand for the orphan G-protein coupled receptor GPR14. Biochem. Biophys. Res. Commun., 1999, 266, 174-178.
[12]
Libert, F.; Vassart, G.; Parmentier, M. Current developments in G-protein- coupled receptors. Curr. Opin. Cell Biol., 1991, 8, 218-223.
[13]
Ames, R.S.; Sarau, H.M.; Chambers, J.K.; Willette, R.N.; Aiyar, N.V.; Romanic, A.M.; Louden, C.S.; Foley, J.J.; Sauermelch, C.F.; Coatney, R.W.; Ao, Z.; Disa, J.; Holmes, S.D.; Stadel, J.M.; Martin, J.D.; Liu, W.S.; Glover, G.I.; Wilson, S.; McNulty, D.E.; Ellis, C.E.; Elshourbagy, N.A.; Shabon, U.; Trill, J.J.; Hay, D.W.; Ohlstein, E.H.; Bergsma, D.J.; Douglas, S.A. Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14. Nature, 1999, 401, 282-286.
[14]
Matsushita, M.; Shichiri, M.; Imai, T.; Iwashina, M.; Tanaka, H.; Takasu, N.; Hirata, Y. Co-expression of urotensin II and its receptor (GPR14) in human cardiovascular and renal tissues. J. Hypertens., 2001, 19, 2185-2190.
[15]
Douglas, S.A.; Tayara, L.; Ohlstein, E.H.; Halawa, N.; Giaid, A. Congestive heart failure and expression of myocardial urotensin II. Lancet, 2002, 359, 1990-1997.
[16]
Dubessy, C.; Cartier, D.; Lectez, B.; Bucharles, C.; Chartrel, N.; Montero-Hadjadje, M.; Bizet, P.; Chatenet, D.; Tostivint, H.; Scalbert, E.; Leprince, J.; Vaudry, H.; Jégou, S.; Lihrmann, I. Characterization of urotensin II, distribution of urotensin II, urotensin II-related peptide and UT receptor mRNAs in mouse: evidence of urotensin II at the neuromuscular junction. J. Neurochem., 2008, 107, 361-374.
[17]
Chartrel, N.; Leprince, J.; Dujardin, C.; Chatenet, D.; Tollemer, H.; Baroncini, M.; Balment, R.J.; Beauvillain, J.C.; Vaudry, H. Biochemical characterization and immunohistochemical localization of urotensin II in the human brainstem and spinal cord. J. Neurochem., 2004, 91, 110-118.
[18]
MacLean, M.R.; Alexander, D.; Stirrat, A.; Gallagher, M.; Douglas, S.A.; Ohlstein, E.H.; Morecroft, I.; Polland, K. Contractile response to human urotensin- II in rat and human pulmonary arteries: effect of endothelial factors and chronic hypoxia in the rat. Br. J. Pharmacol., 2000, 130, 201-204.
[19]
Douglas, S.A.; Sulpizio, A.C.; Piercy, V.; Sarau, H.M.; Ames, R.S.; Aiyar, N.V.; Ohlstein, E.H.; Willette, R.N. Differential vasoconstrictor activity of human urotensin-II in vascular tissue isolated from the rat, mouse, dog, pig, marmoset and cynomolgus monkey. Br. J. Pharmacol., 2001, 131, 1262-1274.
[20]
Hay, D.; Luttmann, M.A.; Douglas, S.A. Human urotensin-II is a potent spasmogen of primate airway smooth muscle. Br. J. Pharmacol., 2000, 131, 10-12.
[21]
Thanassoulis, G.; Huyhn, T.; Giaid, A. Urotensin II and cardiovascular diseases. Peptides, 2004, 25, 1789-1794.
[22]
Zhu, Y.C.; Zhu, Y.Z.; Moore, P.K. The role of Urotensin II in cardiovascular and renal physiology and diseases. Br. J. Pharmacol., 2006, 148, 884-901.
[23]
Conlon, J.M.; Yano, K.; Waugh, D.; Hazon, N. Distribution and molecular forms of urotensin II and its role in cardiovascular regulation in vertebrates. J. Exp. Zool., 1996, 275, 226-238.
[24]
Coulouarn, Y.; Lihrmann, I.; Jegou, S.; Anouar, Y.; Tostivint, H.; Beauvillain, J.C.; Conlon, J.M.; Bern, H.A.; Vaudry, H. Cloning of the cDNA encoding the urotensin II precursor in frog and human reveals intense expression of the urotensin II gene in motoneurons of the spinal cord. Proc. Natl. Acad. Sci. USA, 1998, 95, 15803-15808.
[25]
Vaudry, H.; Leprince, J.; Chatenet, D.; Fournier, A.; Lambert, D.G.; Le Mével, J.C.; Ohlstein, E.H.; Schwertani, A.; Tostivint, H.; Vaudry, D. International Union of Basic and Clinical Pharmacology. XCII. Urotensin II, urotensin II-related peptide, and their receptor: from structure to function. Pharmacol. Rev., 2015, 67, 214-258.
[26]
Saetrum Opgaard, O.; Nothacker, H.; Ehlert, F.J.; Krause, D.N. Human urotensin II mediates vasoconstriction via an increase in inositol phosphates. Eur. J. Pharmacol., 2000, 406, 265-271.
[27]
Parys, J.B.; De Smedt, H. Inositol 1,4,5-trisphosphate and its receptors. Adv. Exp. Med. Biol., 2012, 740, 255-279.
[28]
Ziltener, P.; Mueller, C.; Haenig, B.; Scherz, M.W.; Nayler, O. Urotensin II mediates ERK1/2 phosphorylation and proliferation in GPR14-transfected cell lines. J. Recept. Signal Transduct. Res., 2002, 22, 155-168.
[29]
Sauzeau, V.; Le Mellionnec, E.; Bertoglio, J.; Scalbert, E.; Pacaud, P.; Loirand, G. Human urotensin II-induced contraction and arterial smooth muscle cell proliferation are mediated by RhoA and Rho-kinase. Circ. Res., 2001, 88, 1102-1104.
[30]
Joyal, D.; Huynh, T.; Aiyar, N.; Guida, B.; Douglas, S.; Giaid, A. Urotensin-II levels in acute coronary syndromes. Int. J. Cardiol., 2006, 108(1), 31-35.
[31]
Gruson, D.; Ginion, A.; Decroly, N.; Lause, P.; Vanoverschelde, J.L.; Ketelslegers, J.M.; Bertrand, L.; Thissen, J.P. Urotensin II induction of adult cardiomyocytes hypertrophy involves the Akt/GSK-3beta signaling pathway. Peptides, 2010, 31, 1326-1333.
[32]
Behm, D.J.; Ao, Z.; Camarda, V.; Aiyar, N.V.; Johns, D.G.; Douglas, S.A. Inhibitory effects of putative peptidic urotensin-II receptor antagonists on urotensin-II-induced contraction of cat isolated respiratory smooth muscle. Eur. J. Pharmacol., 2005, 516, 276-281.
[33]
Trebicka, J.; Leifeld, L.; Hennenberg, M.; Biecker, E.; Eckhardt, A.; Fischer, N.; Pröbsting, A.S.; Clemens, C.; Lammert, F.; Sauerbruch, T.; Heller, J. Hemodynamic effects of urotensin II and its specific receptor antagonist palosuran in cirrhotic rats. Hepatology, 2008, 47(4), 1264-1276.
[34]
Pehlivan, Y.; Dokuyucu, R.; Demir, T.; Kaplan, D.S.; Koc, I.; Orkmez, M.; Turkbeyler, I.H.; Ceribasi, A.O.; Tutar, E.; Taysi, S.; Kisacik, B.; Onat, A.M. Palosuran treatment effective as bosentan in the treatment model of pulmonary arterial hypertension. Inflammation, 2014, 37, 1280-1288.
[35]
He, W.Y.; Chen, G.J.; Lai, X.; Wu, F.; Tang, C.S.; Zhang, A.H. Expression levels of urotensin II are associated with endoplasmic reticulum stress in patients with severe preeclampsia. J. Hum. Hypertens., 2015, 30, 129-135.
[36]
Liu, W.; Han, Q.; Liu, Q.; Liang, G.; Wang, J.; Liu, C. An investigation into the expression and mechanism of action of urotensin II in chronic pressure-overloaded rat hearts. Mol. Med. Rep., 2015, 12, 6626-6634.
[37]
Oh, K.S.; Lee, J.H.; Yi, K.Y.; Lim, C.J.; Lee, S.; Park, C.H.; Seo, H.W.; Lee, B.H. The orally active urotensin receptor antagonist, KR36676, attenuates cellular and cardiac hypertrophy. Br. J. Pharmacol., 2015, 172, 2618-2633.
[38]
Aita, Y.; Kasahara, T.; Isobe, K.; Kawakami, Y.; Takekoshi, K. Effect of urotensin II on PC12 rat pheochromocytoma cells. J. Neuroendocrinol., 2010, 22(2), 83-91.
[39]
Esposito, G.; Perrino, C.; Cannavo, A.; Schiattarella, G.G.; Borgia, F.; Sannino, A.; Pironti, G.; Gargiulo, G.; Di Serafino, L.; Franzone, A.; Scudiero, L.; Grieco, P.; Indolfi, C.; Chiariello, M. EGFR trans-activation by urotensin II receptor is mediated by β-arrestin recruitment and confers cardioprotection in pressure overload-induced cardiac hypertrophy. Basic Res. Cardiol., 2011, 106, 577-589.
[40]
d’Emmanuele di Villa Bianca, R.; Cirino, G.; Mitidieri, E.; Coletta, C.; Grassia, G.; Roviezzo, F.; Grieco, P.; Novellino, E.; Imbimbo, C.; Mirone, V.; Sorrentino, R. Urotensin II: a novel target in human corpus cavernosum. J. Sex. Med., 2010, 7, 1778-1786.
[41]
di Villa Bianca, Rd.; Mitidieri, E.; Donnarumma, E.; Fusco, F.; Longo, N.; Rosa, G.D.; Novellino, E.; Grieco, P.; Mirone, V.; Cirino, G.; Sorrentino, R. A new therapeutic approach to erectile dysfunction: urotensin-II receptor high affinity agonist ligands. Asian J. Androl., 2015, 17, 81-85.
[42]
Abdel-Razik, A.E.; Balment, R.J.; Ashton, N. Enhanced renal sensitivity of the spontaneously hypertensive rat to urotensin II. Am. J. Physiol. Renal Physiol., 2008, 295, 1239-1247.
[43]
Adebiyi, A. RGS2 regulates urotensin II-induced intracellular Ca2+ elevation and contraction in glomerular mesangial cells. J. Cell. Physiol., 2014, 229(4), 502-511.
[44]
Debiec, R.; Christofidou, P.; Denniff, M.; Bloomer, L.D.; Bogdanski, P.; Wojnar, L.; Musialik, K.; Charchar, F.J.; Thompson, J.R.; Waterworth, D.; Song, K.; Vollenweider, P.; Waeber, G.; Zukowska-Szczechowska, E.; Samani, N.J.; Lambert, D.; Tomaszewski, M. Urotensin-II system in genetic control of blood pressure and renal function. PLoS One, 2013, 8(12), e83137.
[45]
Balat, A.; Büyükçelik, M. Urotensin-II: More Than a Mediator for Kidney. Int. J. Nephrol, 2012. 2012, 249790.
[46]
Heller, J.; Schepke, M.; Neef, M.; Woitas, R.; Rabe, C.; Sauerbruch, T. Increased urotensin II plasma levels in patients with cirrhosis and portal hypertension. J. Hepatol., 2002, 37, 767-772.
[47]
Kemp, W.; Krum, H.; Colman, J.; Bailey, M.; Yandle, T.; Richards, M.; Roberts, S. Urotensin II: a novel vasoactive mediator linked to chronic liver disease and portal hypertension. Liver Int., 2007, 27, 1232-1239.
[48]
Rosso, N.; Chavez-Tapia, N.C.; Tiribelli, C.; Bellentani, S. Translational approaches: from fatty liver to non-alcoholic steatohepatitis. World J. Gastroenterol., 2014, 20, 9038-9049.
[49]
Watanabe, T.; Kanome, T.; Suguro, T.; Miyazaki, A. Human Urotensin II and Metabolic Syndrome. Vasc. Dis. Prev., 2006, 3(2), 91-98.
[50]
Xie, N.; Liu, L. Elevated expression of urotensin II and its receptor in great artery of type 2 diabetes and its significance. Biomed. Pharmacother., 2009, 63(10), 734-741.
[51]
Elshourbagy, N.A.; Douglas, S.A.; Shabon, U.; Harrison, S.; Duddy, G.; Sechler, J.L.; Ao, Z.; Maleeff, B.E.; Naselsky, D.; Disa, J.; Aiyar, N.V. Molecular and pharmacological characterization of genes encoding urotensin-II peptides and their cognate G-protein- coupled receptors from the mouse and monkey. Br. J. Pharmacol., 2002, 136, 9-22.
[52]
Totsune, K.; Takahashi, K.; Arihara, Z.; Sone, M.; Ito, S.; Murakami, O. Increased plasma urotensin II levels in patients with diabetes mellitus. Clin. Sci., 2003, 104, 1-5.
[53]
Leifeld, L.; Clemens, C.; Heller, J.; Trebicka, J.; Sauerbruch, T.; Spengler, U. Expression of urotensin II and its receptor in human liver cirrhosis and fulminant hepatic failure. Dig. Dis. Sci., 2010, 55(5), 1458-1464.
[54]
You, Z.; Al Kindi, H.; Abdul-Karim, A.; Barrette, P.O.; Schwertani, A. Blocking the urotensin II receptor pathway ameliorates the metabolic syndrome and improves cardiac function in obese mice. FASEB J., 2014, 28, 1210-1220.
[55]
Barrette, P.O.; Schwertani, AG. A closer look at the role of urotensin II in the metabolic syndrome. Front Endocrinol. (Lausanne), 2012. 28, 3, 165.
[56]
You, Z.; Genest, J., Jr; Barrette, P.O.; Hafiane, A.; Behm, D.J.; D’Orleans-Juste, P.; Schwertani, A.G. Genetic and pharmacological manipulation of urotensin II ameliorate the metabolic and atherosclerosis sequalae in mice. Arterioscler. Thromb. Vasc. Biol., 2012, 32, 1809-1816.
[57]
Bulbul, F.; Alpak, G.; Unal, A.; Copoglu, U.S.; Orkmez, M.; Virit, O.; Tarkcıoglu, M.; Savas, H.A. New molecule in the etiology of schizophrenia: urotensin II. Psychiatry Clin. Neurosci., 2014, 68, 133-136.
[58]
Romanelli, R.G.; Laffi, G.; Vizzutti, F.; Del Bene, R.; Marra, F.; Caini, P.; Guerra, C.T. La villa, G.; Barletta, G. Elevated plasma levels of urotensin II do not correlate with systemic haemodynamics in patients with cirrhosis. Dig. Liver Dis., 2011, 43(4), 314-318.
[59]
Kristof, A.S.; You, Z.; Han, Y.S.; Giaid, A. Protein expression of urotensin II, urotensin-related peptide and their receptor in the lungs of patients with lymphangioleiomyomatosis. Peptides, 2010, 31, 1511-1516.
[60]
Federico, A.; Zappavigna, S.; Romano, M.; Grieco, P.; Luce, A.; Marra, M.; Gravina, A.G.; Stiuso, P.; D’Armiento, F.P.; Vitale, G.; Tuccillo, C.; Novellino, E.; Loguercio, C.; Caraglia, M. Urotensin-II receptor is over-expressed in colon cancer cell lines and in colon carcinoma in humans. Eur. J. Clin. Invest., 2014, 44, 285-294.
[61]
Grieco, P.; Franco, R.; Bozzuto, G.; Toccacieli, L.; Sgambato, A.; Marra, M.; Zappavigna, S.; Migaldi, M.; Rossi, G.; Striano, S.; Marra, L.; Gallo, L.; Cittadini, A.; Botti, G.; Novellino, E.; Molinari, A.; Budillon, A.; Caraglia, M. Urotensin II receptor predicts the clinical outcome of prostate cancer patients and is involved in the regulation of motility of prostate adenocarcinoma cells. J. Cell. Biochem., 2011, 112, 341-353.
[62]
Giuliani, L.; Lenzini, L.; Antonello, M.; Aldighieri, E.; Belloni, A.S.; Fassina, A.; Gomez-Sanchez, C.; Rossi, G.P. Expression and functional role of urotensin-II and its receptor in the adrenal cortex and medulla: novel insights for the pathophysiology of primary aldosteronism. J. Clin. Endocrinol. Metab., 2009, 94, 684-690.
[63]
Franco, R.; Zappavigna, S.; Gigantino, V.; Luce, A.; Cantile, M.; Cerrone, M.; Facchini, G.; Perdonà, S.; Pignata, S.; Di Lorenzo, G.; Chieffi, S.; Vitale, G.; De Sio, M.; Sgambato, A.; Botti, G.; Yousif, A.M.; Novellino, E.; Grieco, P.; Caraglia, M. Urotensin II receptor determines prognosis of bladder cancer regulating cell motility/invasion. J. Exp. Clin. Cancer Res., 2014, 33, 48.
[64]
Wang, H.; Dong, K.; Xue, X.; Feng, P.; Wang, X. Elevated expression of urotensin II and its receptor in diethylnitrosamine-mediated precancerous lesions in rat liver. Peptides, 2011, 32, 382-387.
[65]
Yu, X.T.; Wang, P.Y.; Shi, Z.M.; Dong, K.; Feng, P.; Wang, H.X.; Wang, X.J. Up-regulation of urotensin II and its receptor contributes to human hepatocellular carcinoma growth via activation of the PKC, ERK1/2, and p38 MAPK signaling pathways. Molecules, 2014, 19, 20768-20779.
[66]
Balakan, O.; Kalender, M.E.; Suner, A.; Cengiz, B.; Oztuzcu, S.; Bayraktar, R.; Borazan, E.; Babacan, T.; Camci, C. The relationship between urotensin II and its receptor and the clinicopathological parameters of breast cancer. Med. Sci. Monit., 2014, 20, 1419-1425.
[67]
Ross, B.; McKendy, K.; Giaid, A. Role of urotensin II in health and disease. Am. J. Physiol. Regul. Integr. Comp. Physiol., 2010, 298(5), R1156-R1172.
[68]
Takahashi, K.; Totsune, K.; Murakami, O.; Shibahara, S. Expression of urotensin II and urotensin II receptor mRNAs in various human tumor cell lines and secretion of urotensin II-like immunoreactivity by SW-13 adrenocortical carcinoma cells. Peptides, 2001, 22, 1175-1179.
[69]
Takahashi, K.; Totsune, K.; Murakami, O. Expression of three vasoactive peptides, urotensin II, adrenomedullin and endothelin-1, in a human renal cell carcinoma cell line, VMRC-RCW. Clin. Exp. Nephrol., 2002, 5, 246-249.
[70]
Takahashi, K.; Totsune, K.; Kitamuro, T.; Sone, M.; Murakami, O.; Shibahara, S. Three vasoactive peptides, endothelin-1, adrenomedullin and urotensin-II, in human tumor cell lines of different origin: expression and effects on proliferation. Clin. Sci., 2000, 103, 35-38.
[71]
Johansson, J.E.; Holmberg, L.; Johansson, S.; Bergström, R.; Adami, H.O. Fifteen year survival in prostate cancer. A prospective, population-based study in Sweden. JAMA, 1997, 277, 467-471.
[72]
Albertsen, P.C.; Hanley, J.A. Fine 20-year outcomes following conservative management of clinically localized prostate cancer. JAMA, 2005, 293, 2095-2101.
[73]
Halabi, S.; Small, E.J.; Kantoff, P.W.; Kattan, M.W.; Kaplan, E.B.; Dawson, N.A. Prognostic model for predicting survival in men with hormone-refractory metastatic prostate cancer. J. Clin. Oncol., 2003, 21, 1232-1237.
[74]
Gleason, D.F.; Mellinger, G.T. Prediction of prognosis for prostatic adenocarcinoma by combined histological grading and clinical staging. J. Urol., 1974, 11, 58-64.
[75]
Cobelli, O.; Buonerba, C.; Terracciano, D.; Danilo, B.; Giuseppe, L.; Bove, P.; Altieri, V.; Coman, I.; Perdonà, S.; Facchini, G.; Berretta, M.; Lorenzo, G.D.; Grieco, P.; Novellino, E.; Franco, R.; Caraglia, M.; Manini, C.; Mirone, V.; Placido, S.; Sonpavde, G.; Ferro, M. Urotensin II receptor on preoperative biopsy is associated with upstaging and upgrading in prostate cancer. Future Oncol., 2015, 11, 3091-3098.
[76]
Jemal, A.; Siegel, R.; Ward, E.; Hao, Y.; Xu, J.; Thun, M. J. Cancer statistics, 2009. CA Cancer J. Clin., 2009, 59, 225-249.
[77]
Sengupta, S.; Blute, M.L. The management of superficial transitional cell carcinoma of the bladder. Urology, 2006, 67, 48-54.
[78]
Murphy, W.M.; Takezawa, K.; Maruniak, N.A. Interobserver discrepancy using the 1998 World Health Organization/International Society of Urologic Pathology classification of urothelial neoplasms: practical choices for patient care. J. Urol., 2002, 168, 968-972.
[79]
Onan, D.; Hannan, R.D.; Thomas, W.G. Urotensin II: the old kid in town. Trends Endocrinol. Metab., 2004, 15, 175-182.
[80]
Yoshimoto, T.; Matsushita, M.; Hirata, Y. Role of urotensin II in peripheral tissue as an autocrine/paracrine growth factor. Peptides, 2004, 25, 1775-1781.
[81]
Watanabe, T. Kanome1, T.; Miyazaki, A.; Katagiri, T. Human Urotensin II as a Link between Hypertension and Coronary Artery Disease. Hypertens. Res., 2006, 29, 375-387.
[82]
Charles, C.J.; Rademaker, M.T.; Richards, A.M.; Yandle, T.G. Urotensin II: evidence for cardiac, hepatic and renal production. Peptides, 2005, 26, 2211-2214.
[83]
Liu, D.; Chen, J.; Wang, J.; Zhang, Z.; Ma, X.; Jia, J.; Wang, Y. Increased expression of urotensin II and GPR14 in patients with cirrhosis and portal hypertension. Int. J. Mol. Med., 2010, 25, 845-851.
[84]
Janz, N.K.; Wren, P.A.; Schottenfeld, D.; Guire, K.E. Colorectal cancer screening attitudes and behavior: a population-based study. Prev. Med., 2003, 37(6 Pt1), 627-634.
[85]
Haq, S.; Ali, S.; Mohammad, R.; Sarkar, F.H. The complexities of epidemiology and prevention of gastrointestinal cancers. Int. J. Mol. Sci., 2012, 13, 12556-12572.
[86]
Labianca, R.; Beretta, G.; Bozzetti, F.; Milesi, L.; Mosconi, S.; Quadri, A. Neoplasie dell’apparato digerente. Elsevier Masson: Italy, 2009; pp. 1015-1101.
[87]
Qiu, Y.; Zhou, B.; Su, M.; Baxte, S.; Zheng, X.; Zhao, X.; Yen, Y.; Jia, W. Mass spectrometry-based quantitative metabolomics revealed a distinct lipid profile in breast cancer patients. Int. J. Mol. Sci., 2013, 14(4), 8047-8061.
[88]
Winkfield, K.M.; Harris, J.R. Effective local therapy and long-term survival in breast cancer. Oncology, 2009, 23(8), 669-675.
[89]
Jordan, V.C. Pak up your breast tumor--and grow! Natl. Cancer Inst., 2006, 98(10), 657-659.
[90]
Yumrutas, O.; Oztuzcu, S.; Büyükhatipoglu, H.; Bozgeyik, I.; Bozgeyik, E.; Igci, Y.Z.; Bagis, H.; Cevik, M.O.; Kalender, M.E.; Eslik, Z.; Arslan, A. The role of the UTS2 gene polymorphisms and plasma Urotensin-II levels in breast cancer. Tumour Biol., 2015, 36, 4427-4432.
[91]
Addeo, R.; Caraglia, M.; De Santi, M.S.; Montella, L.; Abbruzzese, A.; Parlato, C.; Vincenzi, B.; Carraturo, M.; Faiola, V.; Genovese, M.; Cennamo, G.; Del Prete, S. A new schedule of fotemustine in temozolomide-pretreated patients with relapsing glioblastoma. J. Neurooncol., 2011, 102(3), 417-424. [Erratum in: J. Neurooncol.,2011, 102]. [3].
[92]
Addeo, R.; De Santi, M.S.; Del Prete, S.; Caraglia, M. Fotemustine and recurrentglioblastoma: possible new opportunities for an old drug. Cancer Chemother. Pharmacol., 2009, 64(5), 863-866.
[93]
Stupp, R.; Hegi, M.E.; Mason, W.P.; van den Bent, M.J.; Taphoorn, M.J.; Janzer, R.C.; Ludwin, S.K.; Allgeier, A.; Fisher, B.; Belanger, K.; Hau, P.; Brandes, A.A.; Gijtenbeek, J.; Marosi, C.; Vecht, C.J.; Mokhtari, K.; Wesseling, P.; Villa, S.; Eisenhauer, E.; Gorlia, T.; Weller, M.; Lacombe, D.; Cairncross, J.G.; Mirimanoff, R.O. National Cancer Institute of Canada Clinical Trials Group. Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial. Lancet Oncol., 2009, 10, 459-466.
[94]
Desrues, L.; Lefebvre, T.; Lecointre, C.; Schouft, M.T.; Leprince, J.; Compère, V.; Morin, F.; Proust, F.; Gandolfo, P.; Tonon, M.C.; Castel, H. Down-regulation of GABA(A) receptor via promiscuity with the vasoactive peptide urotensin II receptor. Potential involvement in astrocyte plasticity. PLoS One, 2012, 7, e36319.
[95]
Lecointre, C.; Desrues, L.; Joubert, J.E.; Perzo, N.; Guichet, P.O.; Le Joncour, V.; Brulé, C.; Chabbert, M.; Leduc, R.; Prézeau, L.; Laquerrière, A.; Proust, F.; Gandolfo, P.; Morin, F.; Castel, H. Signaling switch of the urotensin II vasosactive peptide GPCR: prototypic chemotaxic mechanism in glioma. Oncogene, 2015, 34, 5080-5094.
[96]
Brulé, C.; Perzo, N.; Joubert, J.E.; Sainsily, X.; Leduc, R.; Castel, H.; Prézeau, L. Biased signaling regulates the pleiotropic effects of the urotensin II receptor to modulate its cellular behaviors. FASEB J., 2014, 28, 5148-5162.
[97]
Grieco, P.; Carotenuto, A.; Campiglia, P.; Zampelli, E.; Patacchini, R.; Maggi, C.A.; Novellino, E.; Rovero, P. A new potent Urotensin II receptor peptide agonist containing a Pen residue at the disulfide bridge. J. Med. Chem., 2002, 45, 4391-4394.
[98]
Novellino, E.; Grieco, P.; Rovero, P. Cyclic peptides acting as urotensin II antagonists, and use in the treatment of hypertension and other cardiovascular conditions and in urotensin II receptor characterization. WO Patent 2005023845 A2, March 17, 2005.
[99]
Chatenet, D.; Dubessy, C.; Boularan, C.; Scalbert, E.; Pfeiffer, B.; Renard, P.; Lihrmann, I.; Pacaud, P.; Tonon, M.C.; Vaudry, H.; Leprince, J. Structure-activity relationships of a novel series of urotensin II analogues: identification of a urotensin II antagonist. J. Med. Chem., 2006, 49(24), 7234-7238.
[100]
Carotenuto, A.; Auriemma, L.; Merlino, F.; Yousif, A.M.; Marasco, D.; Limatola, A.; Campiglia, P.; Gomez-Monterrey, I.; Santicioli, P.; Meini, S.; Maggi, C.A.; Novellino, E.; Grieco, P. Lead optimization of P5U and urantide: discovery of novel potent ligands at the urotensin-II receptor. J. Med. Chem., 2014, 57, 5965-5974.
[101]
Grieco, P.; Carotenuto, A.; Campiglia, P.; Marinelli, L.; Lama, T.; Patacchini, R.; Santicioli, P.; Maggi, C.A.; Rovero, P.; Novellino, E. Urotensin-II receptor ligands. From agonist to antagonist activity. J. Med. Chem., 2005, 48, 7290-7297.
[102]
Patacchini, R.; Santicioli, P.; Giuliani, S.; Grieco, P.; Novellino, E.; Rovero, P.; Maggi, C.A. Urantide: an ultrapotent urotensin II antagonist peptide in the rat aorta. Br. J. Pharmacol., 2003, 140, 1155-1158.
[103]
Chatenet, D.; Létourneau, M.; Nguyen, Q.T.; Doan, N.D.; Dupuis, J.; Fournier, A. Discovery of new antagonists aimed at discriminating UII and URP-mediated biological activities: insight into UII and URP receptor activation. Br. J. Pharmacol., 2013, 168, 807-821.
[104]
Chatenet, D.; Folch, B.; Feytens, D.; Létourneau, M.; Tourwé, D.; Doucet, N.; Fournier, A. Development and pharmacological characterization of conformationally constrained urotensin II-related peptide agonists. J. Med. Chem., 2013, 56, 9612-9622.
[105]
Chatenet, D.; Nguyen, T.T.; Létourneau, M.; Fournier, A. Update on the urotensinergic system: new trends in receptor localization, activation, and drug design. Front. Endocrinol. (Lausanne), 2013, 3, 174.
[106]
Clozel, M.; Binkert, C.; Birker-Robaczewska, M.; Boukhadra, C.; Ding, S.S.; Fischli, W.; Hess, P.; Mathys, B.; Morrison, K.; Müller, C.; Müller, C.; Nayler, O.; Qiu, C.; Rey, M.; Scherz, M.W.; Velker, J.; Weller, T.; Xi, J.F.; Ziltener, P. Pharmacology of the urotensin-II receptor antagonist palosuran (ACT-058362);1- [2-(4-benzyl-4-hydroxypiperidin-1-yl)-ethyl]-3-(2-methyl-quinolin-4-yl)-urea sulfate salt): First demonstration of a pathophysiological role of the urotensin system. J. Pharmacol. Exp. Ther., 2004, 311, 204-212.
[107]
Kaiser, E.; Colescott, R.L.; Bossinger, C.D.; Cook, P.I. Color test for detection of free terminal amino groups in the solid-phase synthesis of peptides. Anal. Biochem., 1970, 34, 595-598.
[108]
Maryanoff, B.E.; Kinney, W.A. Urotensin-II receptor modulators as potential drugs. J. Med. Chem., 2010, 53, 2695-2708.
[109]
Merlino, F.; Di Maro, S.; Munaim Yousif, A.; Caraglia, M.; Grieco, P. Urotensin-II ligands: An overview from peptide to nonpeptide structures. J. Amino Acids, 2013. 2013, 979016.
[110]
Lescot, E.; Sopkova-de Oliveira Santos, J.; Dubessy, C.; Oulyadi, H.; Lesnard, A.; Vaudry, H.; Bureau, R.; Rault, S. Definition of new pharmacophores for nonpeptide antagonist of human Urotensin-II. Comparison with the 3D-structure of human Urotensin-II and URP. J. Chem. Inf. Model., 2007, 47, 602-612.
[111]
Dufour-Gallant, J.; Chatenet, D.; Lubell, W.D. De novo conception of small molecule modulators based on endogenous peptide ligands: pyrrolodiazepin-2-one γ-turn mimics that differentially modulate urotensin II receptor-mediated vasoconstriction ex vivo. J. Med. Chem., 2015, 58, 4624-4637.
[112]
Watanabe, T.; Arita, S.; Shiraishi, Y.; Suguro, T.; Sakai, T.; Hongo, S.; Miyazaki, A. Human urotensin II promotes hypertension and atherosclerotic cardiovascular diseases. Curr. Med. Chem., 2009, 16(5), 550-563.

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