Abstract
Objective: Dibenzylbutyrolactone lignans represent a unique group of plant secondary metabolites with increasing significance in medicine. This review summarizes their structural characteristics and classification, as well as the biosynthesis starting in the chloroplast, and their supposed biological activity associated with plant defense mechanisms are also discussed. Over 85 natural dibenzylbutyrolactone lignans known to date and their corresponding plant sources are summarized herein for the first time, highlighting a taxon- and organ-specific accumulation of these compounds.
Conclusion: The isolation strategies, applied analytical methods and pharmacological activities of dibenzylbutyrolactone lignans are also thoroughly reviewed.Keywords: Analysis, arctigenin, biosynthesis, chemotaxonomy, dibenzylbutyrolactone, lignan, biological activity.
Mini-Reviews in Medicinal Chemistry
Title:Dibenzylbutyrolactone Lignans – A Review of Their Structural Diversity, Biosynthesis, Occurrence, Identification and Importance
Volume: 17 Issue: 12
Author(s): Anna Solyomváry, Szabolcs Beni and Imre Boldizsar*
Affiliation:
- Department of Plant Anatomy, Eötvös Loránd University, Budapest,Hungary
Keywords: Analysis, arctigenin, biosynthesis, chemotaxonomy, dibenzylbutyrolactone, lignan, biological activity.
Abstract: Objective: Dibenzylbutyrolactone lignans represent a unique group of plant secondary metabolites with increasing significance in medicine. This review summarizes their structural characteristics and classification, as well as the biosynthesis starting in the chloroplast, and their supposed biological activity associated with plant defense mechanisms are also discussed. Over 85 natural dibenzylbutyrolactone lignans known to date and their corresponding plant sources are summarized herein for the first time, highlighting a taxon- and organ-specific accumulation of these compounds.
Conclusion: The isolation strategies, applied analytical methods and pharmacological activities of dibenzylbutyrolactone lignans are also thoroughly reviewed.Export Options
About this article
Cite this article as:
Solyomváry Anna, Beni Szabolcs and Boldizsar Imre*, Dibenzylbutyrolactone Lignans – A Review of Their Structural Diversity, Biosynthesis, Occurrence, Identification and Importance, Mini-Reviews in Medicinal Chemistry 2017; 17 (12) . https://dx.doi.org/10.2174/1389557516666160614005828
DOI https://dx.doi.org/10.2174/1389557516666160614005828 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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