Microwave Assisted Synthetic Approach of New Pyridine based Benzothiazepines: Their Antibacterial and Antifungal Activities

Title:Microwave Assisted Synthetic Approach of New Pyridine based Benzothiazepines: Their Antibacterial and Antifungal Activities

Volume: 3 Issue: 3

Author(s): Navin B. Patel, Hemant R. Patel, Faiyazalam M. Shaikh, Dhanji P. Rajani and Vatsal M. Patel

Affiliation:

Keywords: Antibacterial, antifungal, benzothiazepine, chalcone, microwave, solvent-free.

Abstract: Background: The Present work describe the synthetic protocol of a new series of 2-(4-(2-(5- Ethylpyridin-2-yl)ethoxy)phenyl)-4-(4-substituted)-2,3-dihydrobenzo [b][1,4]thiazepine (5a-j) by the cyclization of chalcones (4a-j) with 2-amino thiophenol by microwave induced solvent free conditions as well as conventional approach.

Methods: The elemental analysis and spectral method (IR, ¹H and ¹³C NMR) were characterized the structure of all synthesized compounds.

Result: These compounds were screened for antibacterial and antifungal activity. Bezothiazepine derivative 5f showed potency (MBC = 50 µg/ml) against gram negative P. aeruginosa and 5i displyed encouraging activity (MFC = 200 µg/ml) against A. niger and A. clavatus.

Conclusion: The solvent less non-conventional microwave induced synthesis of compound (5a-j) has been proven considerable advantageous over conventional methods.

Cite this article as:

Patel B. Navin, Patel R. Hemant, Shaikh M. Faiyazalam, Rajani P. Dhanji and Patel M. Vatsal, Microwave Assisted Synthetic Approach of New Pyridine based Benzothiazepines: Their Antibacterial and Antifungal Activities, Current Microwave Chemistry 2016; 3 (3) . https://dx.doi.org/10.2174/2213335603666160609123550