Abstract
The ever increasing cases of microbial resistance pose a major threat to the scientific community and therefore the need for discovery and development of newer antimicrobial agents with novel mode of action is becoming critical. One of the ways to tackle this herculean problem is to generate hybrid molecules by combining two or more bioactive heterocyclic moieties in a single molecular platform. The review here describes published results of our research group’s endeavors towards development of potential new and safe antimicrobial agents with better effectiveness by using the hybrid approach. In the present review article the landscaping of heterocycles like 4-thiazolidinones, benzimidazole and quinoline are described. Compounds displaying two of more fold antimicrobial activity are included in the review.
Keywords: Antimicrobial agents, benzimidazole, bioactive heterocycles, hybrid molecules, 4-thiazolidinone, quinoline.
Mini-Reviews in Medicinal Chemistry
Title:Hybrid Bioactive Heterocycles as Potential Antimicrobial Agents: A Review
Volume: 16 Issue: 18
Author(s): Nisheeth Desai, Amit Trivedi, Unnat Pandit, Amit Dodiya, V. Kameswara Rao and Priyanka Desai
Affiliation:
Keywords: Antimicrobial agents, benzimidazole, bioactive heterocycles, hybrid molecules, 4-thiazolidinone, quinoline.
Abstract: The ever increasing cases of microbial resistance pose a major threat to the scientific community and therefore the need for discovery and development of newer antimicrobial agents with novel mode of action is becoming critical. One of the ways to tackle this herculean problem is to generate hybrid molecules by combining two or more bioactive heterocyclic moieties in a single molecular platform. The review here describes published results of our research group’s endeavors towards development of potential new and safe antimicrobial agents with better effectiveness by using the hybrid approach. In the present review article the landscaping of heterocycles like 4-thiazolidinones, benzimidazole and quinoline are described. Compounds displaying two of more fold antimicrobial activity are included in the review.
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Cite this article as:
Desai Nisheeth, Trivedi Amit, Pandit Unnat, Dodiya Amit, Rao Kameswara V. and Desai Priyanka, Hybrid Bioactive Heterocycles as Potential Antimicrobial Agents: A Review, Mini-Reviews in Medicinal Chemistry 2016; 16 (18) . https://dx.doi.org/10.2174/1389557516666160609075620
DOI https://dx.doi.org/10.2174/1389557516666160609075620 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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