Abstract
Skin and corneal wounds in diabetics are a major healthcare burden. MicroRNAs are small, non-coding RNAs that post-transcriptionally regulate the expression of proteincoding genes. Studies have identified microRNAs involved in all phases of wound healing. The dysregulation of microRNAs can contribute to impaired or delayed skin and corneal wound healing in diabetics. Here, we present a comprehensive review of the literature involving microRNAs in diabetic skin and corneal wound healing as well as those serving as potential biomarkers for diabetic wound healing.
Keywords: microRNA, wound healing, skin, cornea, diabetes, pathogenesis.
Current Molecular Medicine
Title:Small RNAs Play Big Roles: MicroRNAs in Diabetic Wound Healing
Volume: 16 Issue: 6
Author(s): F. Fahs, X.-L. Bi, F.-S. Yu, L. Zhou and Q.-S. Mi
Affiliation:
Keywords: microRNA, wound healing, skin, cornea, diabetes, pathogenesis.
Abstract: Skin and corneal wounds in diabetics are a major healthcare burden. MicroRNAs are small, non-coding RNAs that post-transcriptionally regulate the expression of proteincoding genes. Studies have identified microRNAs involved in all phases of wound healing. The dysregulation of microRNAs can contribute to impaired or delayed skin and corneal wound healing in diabetics. Here, we present a comprehensive review of the literature involving microRNAs in diabetic skin and corneal wound healing as well as those serving as potential biomarkers for diabetic wound healing.
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Cite this article as:
Fahs F., Bi X.-L., Yu F.-S., Zhou L. and Mi Q.-S., Small RNAs Play Big Roles: MicroRNAs in Diabetic Wound Healing, Current Molecular Medicine 2016; 16 (6) . https://dx.doi.org/10.2174/1566524016666160607091156
DOI https://dx.doi.org/10.2174/1566524016666160607091156 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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