Abstract
Background: Cascade reactions, as an attractive branch of organic chemistry, have been the subject of intense research in the recent years. In these reactions numerous transformations occur in a single sequence, and the subsequent reactions are formed as a consequence of the functionality of the previous step. Cascade reactions are environmentally benign processes due to their one-pot procedure which accordingly proceed in a single reaction solvent, work-up, and purification step. Therefore, they are often associated with cost savings in terms of solvents, catalysts, and reagents in addition to time and effort.
Objective: In the recent years, cascade reactions have been used for the construction of complicated molecular scaffolds, especially heterocyclic natural products. Different naturally occurring compounds were synthesized through cascade (tandem) reactions; this review has been focused on the use of cascade sequences for the synthesis of heterocyclic natural products.Keywords: Cascade reaction, tandem reaction, natural products, heterocycles, total synthesis, one-pot procedure.
Current Organic Chemistry
Title:Cascade Reaction in the Synthesis of Heterocyclic Natural Products
Volume: 21 Issue: 15
Author(s): Vaezeh Fathi Vavsari and Saeed Balalaie*
Affiliation:
- Peptide Chemistry Research Center, K. N. Toosi University of Technology, P. O. Box 15875-4416, Tehran,Iran
Keywords: Cascade reaction, tandem reaction, natural products, heterocycles, total synthesis, one-pot procedure.
Abstract: Background: Cascade reactions, as an attractive branch of organic chemistry, have been the subject of intense research in the recent years. In these reactions numerous transformations occur in a single sequence, and the subsequent reactions are formed as a consequence of the functionality of the previous step. Cascade reactions are environmentally benign processes due to their one-pot procedure which accordingly proceed in a single reaction solvent, work-up, and purification step. Therefore, they are often associated with cost savings in terms of solvents, catalysts, and reagents in addition to time and effort.
Objective: In the recent years, cascade reactions have been used for the construction of complicated molecular scaffolds, especially heterocyclic natural products. Different naturally occurring compounds were synthesized through cascade (tandem) reactions; this review has been focused on the use of cascade sequences for the synthesis of heterocyclic natural products.Export Options
About this article
Cite this article as:
Vavsari Fathi Vaezeh and Balalaie Saeed*, Cascade Reaction in the Synthesis of Heterocyclic Natural Products, Current Organic Chemistry 2017; 21 (15) . https://dx.doi.org/10.2174/1385272820666160603114213
DOI https://dx.doi.org/10.2174/1385272820666160603114213 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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