Abstract
Aptamers are specific oligonucleotides selected invitro which bind to target molecules with high affinity and specificity like antibody-antigen interactions. For that reason, these synthetic oligonucleotides also known as “artificial antibodies”, offer great potential as bio-recognition elements in biosensors. Electrochemical sensors, as biosensors, are very attractive to early diagnosis of cancer as these devices are fast, portable, extremely sensitive and selective towards their targets, especially when a biorecognition element is integrated with the electrode surface. This review presents electrochemical aptasensors reported in the literature which is sensitive to and specific to cancer cells or their marker proteins, and their possible improvements by combining nanotechnology.
Keywords: Early cancer diagnosis, electrochemical biosensors, aptasensor, nanoparticles, graphene, cancer cell, biomarkers.
Current Analytical Chemistry
Title:Electrochemical Aptasensors for Early Cancer Diagnosis: A Review
Volume: 13 Issue: 1
Author(s): Mustafa Oguzhan Caglayan
Affiliation:
Keywords: Early cancer diagnosis, electrochemical biosensors, aptasensor, nanoparticles, graphene, cancer cell, biomarkers.
Abstract: Aptamers are specific oligonucleotides selected invitro which bind to target molecules with high affinity and specificity like antibody-antigen interactions. For that reason, these synthetic oligonucleotides also known as “artificial antibodies”, offer great potential as bio-recognition elements in biosensors. Electrochemical sensors, as biosensors, are very attractive to early diagnosis of cancer as these devices are fast, portable, extremely sensitive and selective towards their targets, especially when a biorecognition element is integrated with the electrode surface. This review presents electrochemical aptasensors reported in the literature which is sensitive to and specific to cancer cells or their marker proteins, and their possible improvements by combining nanotechnology.
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Cite this article as:
Caglayan Oguzhan Mustafa, Electrochemical Aptasensors for Early Cancer Diagnosis: A Review, Current Analytical Chemistry 2017; 13 (1) . https://dx.doi.org/10.2174/1573411012666160601142051
DOI https://dx.doi.org/10.2174/1573411012666160601142051 |
Print ISSN 1573-4110 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6727 |
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