Abstract
Background: Usnic acid has been progressively reported in the literature as one of the most important lichen metabolites characterized by a rich diversity of applications such as antifungal, antimicrobial, antiprotozoal and antiviral agent. Particularly, antimicrobial activity of usnic acid can be improved by encapsulation of active molecules in enteric electrospun fibers, allowing the controlled release of active molecule at specific pH. Few relevant patents to the topic have been reviewed and cited.
Methods: Bactericidal activity of usnic acid-loaded electrospun fibers of Eudragit L-100 and polyvinylpyrrolidone was examined against Staphylococcus aureus using inhibition hales methodology.
Results: The controlled release of active material at high pH is established after 10 minutes of interaction with media and results in reasonable activity against S. aureus, as detected by inhibition hales.
Conclusion: The strong biological activity of usnic acid-loaded electrospun fibers provides a promising application for corresponding material as a bactericidal agent for wound healing treatment.
Keywords: Antibacterial, controlled release, electrospinning, enteric polymers, fibers, usnic acid.
Recent Patents on Nanotechnology
Title:Bactericidal Activity of Usnic Acid-Loaded Electrospun Fibers
Volume: 10 Issue: 3
Author(s): Evando S. Araújo, Eugênia C. Pereira, Mateus M. da Costa, Nicácio H. da Silva and Helinando P. de Oliveira
Affiliation:
Keywords: Antibacterial, controlled release, electrospinning, enteric polymers, fibers, usnic acid.
Abstract: Background: Usnic acid has been progressively reported in the literature as one of the most important lichen metabolites characterized by a rich diversity of applications such as antifungal, antimicrobial, antiprotozoal and antiviral agent. Particularly, antimicrobial activity of usnic acid can be improved by encapsulation of active molecules in enteric electrospun fibers, allowing the controlled release of active molecule at specific pH. Few relevant patents to the topic have been reviewed and cited.
Methods: Bactericidal activity of usnic acid-loaded electrospun fibers of Eudragit L-100 and polyvinylpyrrolidone was examined against Staphylococcus aureus using inhibition hales methodology.
Results: The controlled release of active material at high pH is established after 10 minutes of interaction with media and results in reasonable activity against S. aureus, as detected by inhibition hales.
Conclusion: The strong biological activity of usnic acid-loaded electrospun fibers provides a promising application for corresponding material as a bactericidal agent for wound healing treatment.
Export Options
About this article
Cite this article as:
Araújo S. Evando, Pereira C. Eugênia, da Costa M. Mateus, da Silva H. Nicácio and de Oliveira P. Helinando, Bactericidal Activity of Usnic Acid-Loaded Electrospun Fibers, Recent Patents on Nanotechnology 2016; 10 (3) . https://dx.doi.org/10.2174/1872210510666160517160144
DOI https://dx.doi.org/10.2174/1872210510666160517160144 |
Print ISSN 1872-2105 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-4020 |
Call for Papers in Thematic Issues
Advances in Vanadium and Titanium Resources for High-performance Materials via Nanostructuring and Nanoengineering (updated BMS-NANOTEC-2023-HT-31)
Vanadium and titanium-based materials are ideal candidates for structural and functional materials in aerospace, biomedical engineering, optics, catalysis, energy storage and conversion etc. Vanadium/titanium-based alloys, compounds and materials have a large family with different chemical compositions, dimensions, structures/morphologies, and chemical/physical/mechanical properties, which provides huge opportunities for the development of emerging ...read more
Green Nanotechnology and Nanomaterials for a Sustainable Environment
Green nanotechnology (GN) might wind up being the most efficient platform for achieving the goals of the 2030 Agenda. The goal of GN is to create goods and procedures that are secure, energy-efficient, waste-free, and emit fewer greenhouse gases. Such goods and procedures use renewable resources, and/or their environmental impact ...read more
NANOSTRUCTURED NEUROMORPHIC DEVICES: TOWARDS IN MATERIA COMPUTING
The efforts pursued in the last decade to build up brain-inspired systems with electronic hardware solutions to solve complex data processing tasks, have leaded to the development of a new generation of devices, as memristor crossbar arrays, and their different applications became more and more reliable. One of the basic ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Computational Enzymology and Organophosphorus Degrading Enzymes: Promising Approaches Toward Remediation Technologies of Warfare Agents and Pesticides
Current Medicinal Chemistry Recent Advances in Adenylation Domain Enzymology in Nonribosomal Peptide Biosynthesis
Current Organic Chemistry Disorders of Innate Immunity in Human ageing and effects of Nutraceutical Administration
Endocrine, Metabolic & Immune Disorders - Drug Targets Pulmonary Surfactant Proteins A and D: Innate Immune Functions and Biomarkers for Lung Diseases
Current Pharmaceutical Design Potential Strategies for Minimizing Mechanism-Based Inhibition of Cytochrome P450 3A4
Current Pharmaceutical Design Natural Phenolic Compounds as Cardiovascular Therapeutics: Potential Role of their Antiinflammatory Effects
Current Vascular Pharmacology Pharmacological Exploration of Triazole-based Therapeutics for Alzheimer’s Disease: An Overview
Current Drug Targets Withdrawal Notice: Evaluation of Clinical Profile, Diagnostic Tests, And Prognosis of Crypto-coccal Meningitis in HIV Infected Patients in Western India
Infectious Disorders - Drug Targets Antimicrobial, Antitumor and Side Effects Assessment of a Newly Synthesized Tamoxifen Analog
Current Topics in Medicinal Chemistry 3-Phenyl-1H-Indole-5-Sulfonamides: Structure-Based Drug Design of a Promising Class of Carbonic Anhydrase Inhibitors
Current Pharmaceutical Design Pharmacogenomics – Implications in the Development of HIV-Associated Brain Disease
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Older Adults Prescribed Methadone: A Review of the Literature Across the Life Span from Opiate Initiation to Methadone Maintenance Treatment
Current Drug Abuse Reviews HIV Genomic Mutations Causing Resistance to Antiretroviral Drugs in Seropositive Sicilians
Current HIV Research Natural Aristolochia Alkaloid Aristololactam-β-D-glucoside: Interaction with Biomacromolecules and Correlation to the Biological Perspectives
Mini-Reviews in Medicinal Chemistry Bixin Action in the Healing Process of Rats Mouth Wounds
Current Pharmaceutical Biotechnology Treating Nonthyroidal Illness Syndrome in the Critically Ill Patient: Still a Matter of Controversy
Current Drug Targets Analyzing Gene Expression and Codon Usage Bias in Diverse Genomes Using a Variety of Models
Current Bioinformatics Prediction of Microbe-drug Associations Based on Chemical Structures and the KATZ Measure
Current Bioinformatics Angiotensin-Converting Enzyme 2 Roles in the Pathogenesis of COVID-19
Current Hypertension Reviews Editorial [Hot Topic: Bacterial Vectors for Gene & Cell Therapy (Guest Editors: Mark Tangney & Cormac G.M. Gahan)]
Current Gene Therapy