Abstract
Current therapeutic strategies used in many types of cancer are confronted with the major problem of multidrug resistance (MDR) that can be acquired through several mechanisms. To overcome this limitation, new therapeutic options are being explored involving state-of-the-art technologies. In this respect, small- interfering RNA (siRNA) technology offers the possibility to block the expression of genes that are involved in the MDR development, improving the therapeutic index of anticancer drugs. Nanocarriers are promising delivery systems for small molecule drugs as well as for nucleic acids aiming to target specifically the cancer cells and to counteract MDR. Several types of organic and inorganic nanocarriers will be discussed in this review, together with their advantages and limitations in delivery of targeted siRNAs and cytotoxic drugs, using in vivo and in vitro experiments. Although siRNA-anticancer drug co-delivery employing nanocarriers seems to be associated with a higher antitumor activity than single drug or nucleic acid administration, more studies are needed to evaluate the efficacy and the toxicity of various nanoparticle delivery systems.
Keywords: Multidrug resistance (MDR), nanocarriers, siRNA, drug delivery systems, co-delivery, liposomes, micelleplexes, inorganic nanoparticles.
Current Organic Chemistry
Title:Strategies to Overcome Multi-Drug Resistance in Cancer Cells: the Contribution of siRNA and Nanotechnologies
Volume: 20 Issue: 28
Author(s): Cristina Mambet, Mihaela Chivu-Economescu, Lilia Matei, Mihai Stoian and Coralia Bleotu
Affiliation:
Keywords: Multidrug resistance (MDR), nanocarriers, siRNA, drug delivery systems, co-delivery, liposomes, micelleplexes, inorganic nanoparticles.
Abstract: Current therapeutic strategies used in many types of cancer are confronted with the major problem of multidrug resistance (MDR) that can be acquired through several mechanisms. To overcome this limitation, new therapeutic options are being explored involving state-of-the-art technologies. In this respect, small- interfering RNA (siRNA) technology offers the possibility to block the expression of genes that are involved in the MDR development, improving the therapeutic index of anticancer drugs. Nanocarriers are promising delivery systems for small molecule drugs as well as for nucleic acids aiming to target specifically the cancer cells and to counteract MDR. Several types of organic and inorganic nanocarriers will be discussed in this review, together with their advantages and limitations in delivery of targeted siRNAs and cytotoxic drugs, using in vivo and in vitro experiments. Although siRNA-anticancer drug co-delivery employing nanocarriers seems to be associated with a higher antitumor activity than single drug or nucleic acid administration, more studies are needed to evaluate the efficacy and the toxicity of various nanoparticle delivery systems.
Export Options
About this article
Cite this article as:
Mambet Cristina, Chivu-Economescu Mihaela, Matei Lilia, Stoian Mihai and Bleotu Coralia, Strategies to Overcome Multi-Drug Resistance in Cancer Cells: the Contribution of siRNA and Nanotechnologies, Current Organic Chemistry 2016; 20 (28) . https://dx.doi.org/10.2174/1385272820666160510163625
DOI https://dx.doi.org/10.2174/1385272820666160510163625 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Advances of Heterocyclic Chemistry with Pesticide Activity
Global food safety and security will continue to be a global concern for the next 50 years and beyond. Plant diseases have had a significant impact on food safety and security throughout the entire food chain, from primary production to consumption. While conventional chemical pesticides have been traditionally used for ...read more
Calculation design of covalent/metal organic framework based catalysts
This research area combines theoretical computation and screening with machine learning for the design of covalent/metal organic framework-based catalysts, bridging the disciplines of organic chemistry, physical chemistry, computational chemistry, materials science, and machine learning. It covers several critical aspects: designing and synthesizing organic catalysts for improved performance, applying computational methods ...read more
Carbohydrates conversion in biofuels and bioproducts
Biomass pretreatment, hydrolysis, and saccharification of carbohydrates, and sugars bioconversion in biofuels and bioproducts within a biorefinery framework. Carbohydrates derived from woody biomass, agricultural wastes, algae, sewage sludge, or any other lignocellulosic feedstock are included in this issue. Simulation, techno-economic analysis, and life cycle analysis of a biorefinery process are ...read more
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Endocannabinoid System: Emerging Role from Neurodevelopment to Neurodegeneration
Mini-Reviews in Medicinal Chemistry Pharmacological Properties and Therapeutic Potential of Naringenin: A Citrus Flavonoid of Pharmaceutical Promise
Current Pharmaceutical Design Poly(Ethylene Glycol) Amphiphilic Copolymer for Anticancer Drugs Delivery
Anti-Cancer Agents in Medicinal Chemistry Plant Coumestans: Recent Advances and Future Perspectives in Cancer Therapy
Anti-Cancer Agents in Medicinal Chemistry Chemoprevention Gene Therapy (CGT) of Pancreatic Cancer Using Perillyl Alcohol and a Novel Chimeric Serotype Cancer Terminator Virus
Current Molecular Medicine Nitroimidazole Radiopharmaceuticals in Hypoxia: Part II Cytotoxicity and Radiosensitization Applications
Current Radiopharmaceuticals Novel Oncogenic Protein Kinase Inhibitors for Cancer Therapy
Current Medicinal Chemistry - Anti-Cancer Agents Cell to Cell Spreading of Misfolded Proteins as a Therapeutic Target in Motor Neuron Disease
Current Medicinal Chemistry Metabolic Dysfunction in Alzheimers Disease and Related Neurodegenerative Disorders
Current Alzheimer Research The Potential of T Cell Immunoglobulin and Mucin-Domain Containing-3 (Tim-3) in Designing Novel Immunotherapy for Bladder Cancer
Endocrine, Metabolic & Immune Disorders - Drug Targets Targeted Tumor Immunotherapy: Are Vaccines the Future of Cancer Treatment?
Current Drug Therapy Nuclear Export as a Novel Therapeutic Target: The CRM1 Connection
Current Cancer Drug Targets Separation and Identification of Antibacterial Chamomile Components Using OPLC, Bioautography and GC-MS
Medicinal Chemistry Hitting the Golden TORget: Curcumin’s Effects on mTOR Signaling
Anti-Cancer Agents in Medicinal Chemistry Acetylome Regulation by Sirtuins in the Brain: From Normal Physiology to Aging and Pathology
Current Pharmaceutical Design RNAi in Clinical Studies
Current Medicinal Chemistry C-glycosyl Flavone from Urginea indica Inhibits Growth and Dissemination of Ehrlich Ascites Carcinoma Cells in Mice
Anti-Cancer Agents in Medicinal Chemistry Detection of Unilateral Hearing Loss by Stationary Wavelet Entropy
CNS & Neurological Disorders - Drug Targets Multi-Modal Imaging and Cancer Therapy Using Lanthanide Oxide Nanoparticles: Current Status and Perspectives
Current Medicinal Chemistry Emerging Concepts in the Analysis of Mitochondrial Genome Instability
Current Genomics