Abstract
Several kinds of polymeric particles designed for drug delivery purposes can be successfully synthesized via heterogeneous polymerization processes. Due to the high ability to produce tailor-made polymers, suspension, mass-suspension, suspension-emulsion, miniemulsion and emulsion polymerization processes deserve special attention in the drug delivery field, as the process operating conditions play a significant role on both the morphology and the macromolecular architecture of the polymeric materials. The present paper also focuses on the main features of important polymer system used in drug delivery, as well as, the cancer therapy, exploring the receptor-based targeting of therapeutics and the cancer recognition mechanisms given special attention to the combined action of immunotherapy and chemotherapy. Dissolution models are also discussed due to their importance to the prediction of the dissolution process and drug release in the blood, providing fundamental insight into the dissolution profiles of the drug along the treatment time.
Keywords: Target delivery, polymers, cancer treatment, polymerization processes, drug delivery system, dissolution models.
Current Organic Chemistry
Title:Target Delivery from Modified Polymers to Cancer Treatment
Volume: 21 Issue: 1
Author(s): Weslany S. Neto, Luis I. Pena, Gabriella R. Ferreira, Fernando G. Souza Junior and Fabricio Machado
Affiliation:
Keywords: Target delivery, polymers, cancer treatment, polymerization processes, drug delivery system, dissolution models.
Abstract: Several kinds of polymeric particles designed for drug delivery purposes can be successfully synthesized via heterogeneous polymerization processes. Due to the high ability to produce tailor-made polymers, suspension, mass-suspension, suspension-emulsion, miniemulsion and emulsion polymerization processes deserve special attention in the drug delivery field, as the process operating conditions play a significant role on both the morphology and the macromolecular architecture of the polymeric materials. The present paper also focuses on the main features of important polymer system used in drug delivery, as well as, the cancer therapy, exploring the receptor-based targeting of therapeutics and the cancer recognition mechanisms given special attention to the combined action of immunotherapy and chemotherapy. Dissolution models are also discussed due to their importance to the prediction of the dissolution process and drug release in the blood, providing fundamental insight into the dissolution profiles of the drug along the treatment time.
Export Options
About this article
Cite this article as:
Neto S. Weslany, Pena I. Luis, Ferreira R. Gabriella, Junior G. Souza Fernando and Machado Fabricio, Target Delivery from Modified Polymers to Cancer Treatment, Current Organic Chemistry 2017; 21 (1) . https://dx.doi.org/10.2174/1385272820666160510151442
DOI https://dx.doi.org/10.2174/1385272820666160510151442 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Advances of Heterocyclic Chemistry with Pesticide Activity
Global food safety and security will continue to be a global concern for the next 50 years and beyond. Plant diseases have had a significant impact on food safety and security throughout the entire food chain, from primary production to consumption. While conventional chemical pesticides have been traditionally used for ...read more
Calculation design of covalent/metal organic framework based catalysts
This research area combines theoretical computation and screening with machine learning for the design of covalent/metal organic framework-based catalysts, bridging the disciplines of organic chemistry, physical chemistry, computational chemistry, materials science, and machine learning. It covers several critical aspects: designing and synthesizing organic catalysts for improved performance, applying computational methods ...read more
Carbohydrates conversion in biofuels and bioproducts
Biomass pretreatment, hydrolysis, and saccharification of carbohydrates, and sugars bioconversion in biofuels and bioproducts within a biorefinery framework. Carbohydrates derived from woody biomass, agricultural wastes, algae, sewage sludge, or any other lignocellulosic feedstock are included in this issue. Simulation, techno-economic analysis, and life cycle analysis of a biorefinery process are ...read more
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Mutant Cell Surface Receptors as Targets for Individualized Cancer Diagnosis and Therapy
Current Cancer Drug Targets Computer-Aided Drug Design of Pyranopyrazoles and Related Compounds for Checkpoint Kinase-1
Letters in Drug Design & Discovery (Iso)Flav(an)ones, Chalcones, Catechins, and Theaflavins as Anticarcinogens: Mechanisms, Anti-Multidrug Resistance and QSAR Studies
Current Medicinal Chemistry Proteasome Inhibitors Therapeutic Strategies for Cancer
Recent Patents on Anti-Cancer Drug Discovery The Management of Metastatic Bone Disease with the Combination of Bisphosphonates and Radiotherapy: From Theory to Clinical Practice
Anti-Cancer Agents in Medicinal Chemistry Telomerase and Survivin in Colorectal and Pancreatic Cancer – Biomarkers of Life and Death in the Balance Between Proliferation and Apoptosis
Current Cancer Therapy Reviews Biodegradable Polymeric Nanoparticles as the Delivery Carrier for Drug
Current Drug Delivery Therapeutic Targeting of the Endoplasmic Reticulum in Alzheimers Disease
Current Alzheimer Research Pd Catalyzed N1/N4 Arylation of Piperazine for Synthesis of Drugs, Biological and Pharmaceutical Targets: An Overview of Buchwald Hartwig Amination Reaction of Piperazine in Drug Synthesis
Current Organic Synthesis Cancer Stem Cells Stemness Transcription Factors Expression Correlates with Breast Cancer Disease Stage
Current Stem Cell Research & Therapy Small Molecule Protein-Protein Inhibitors for the p53-MDM2 Interaction
Current Topics in Medicinal Chemistry Inhibiting the Interaction of cMET and IGF-1R with FAK Effectively Reduces Growth of Pancreatic Cancer Cells in vitro and in vivo
Anti-Cancer Agents in Medicinal Chemistry Recent Advances in Management of Diabetic Macular Edema
Current Diabetes Reviews Personalizing Medicine in Nigeria by Tailoring the Research Process: Points to Consider for Genomic Research
Current Pharmacogenomics and Personalized Medicine Pharmacological Control of Autophagy: Therapeutic Perspectives in Inflammatory Bowel Disease and Colorectal Cancer
Current Pharmaceutical Design Design and Synthesis of a (N-Alkylaminoalkyl-Substituted)Arylalkenylamide Drug Discovery Library
Letters in Drug Design & Discovery Carbon Nanotubes as an Advanced Drug and Gene Delivery Nanosystem
Current Nanoscience Having a Promising Efficacy on Type II Diabetes, It’s Definitely a Green Tea Time
Current Medicinal Chemistry Current Developments in Anti-Fungal Agents
Current Medicinal Chemistry - Anti-Infective Agents Design, Synthesis, Biological Evaluation and In Silico Studies of Few Novel 2-Substituted Benzothiazole Derivatives as Potential EGFR Inhibitors
Letters in Drug Design & Discovery