Abstract
Intracellular Ca2+ signal plays a major role in many cellular processes, such as apoptosis and epithelial to mesenchymal transition (EMT). The role of Ca2+ in apoptotic signaling has been investigated deeply over the past few decades. In recent years, it has made progress in the interactions of intracellular Ca2+ homeostasis with EMT. Besides, Bcl-2 family proteins as versatile regulators of cell apoptosis not only regulate Ca2+ signal, but also play an important role in the induction of EMT. In this review, we summarized the relations among intracellular Ca2+ concentration, apoptosis and Bcl-2 family proteins. We also discussed the functions of intracellular Ca2+ concentration and Bcl-2 family proteins in EMT. By taking into account these analyses; we proposed a hypothesis of cell death and survival controlled by calcium signal.
Keywords: Calcium signal, apoptosis, epithelial to mesenchymal transition, EMT, Bcl-2 family proteins, cancer.
Current Pharmaceutical Design
Title:Bcl-2 Family Proteins Regulate Apoptosis and Epithelial to Mesenchymal Transition by Calcium Signals
Volume: 22 Issue: 30
Author(s): Yanjiao Wu and Liling Tang
Affiliation:
Keywords: Calcium signal, apoptosis, epithelial to mesenchymal transition, EMT, Bcl-2 family proteins, cancer.
Abstract: Intracellular Ca2+ signal plays a major role in many cellular processes, such as apoptosis and epithelial to mesenchymal transition (EMT). The role of Ca2+ in apoptotic signaling has been investigated deeply over the past few decades. In recent years, it has made progress in the interactions of intracellular Ca2+ homeostasis with EMT. Besides, Bcl-2 family proteins as versatile regulators of cell apoptosis not only regulate Ca2+ signal, but also play an important role in the induction of EMT. In this review, we summarized the relations among intracellular Ca2+ concentration, apoptosis and Bcl-2 family proteins. We also discussed the functions of intracellular Ca2+ concentration and Bcl-2 family proteins in EMT. By taking into account these analyses; we proposed a hypothesis of cell death and survival controlled by calcium signal.
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Cite this article as:
Wu Yanjiao and Tang Liling, Bcl-2 Family Proteins Regulate Apoptosis and Epithelial to Mesenchymal Transition by Calcium Signals, Current Pharmaceutical Design 2016; 22 (30) . https://dx.doi.org/10.2174/1381612822666160506125937
DOI https://dx.doi.org/10.2174/1381612822666160506125937 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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