Non-cholesterol Sterols in the Diagnosis and Treatment of Dyslipidemias: A Review

Title:Non-cholesterol Sterols in the Diagnosis and Treatment of Dyslipidemias: A Review

Volume: 23 Issue: 20

Author(s): Lucía Baila-Rueda, Ana Cenarro and Fernando Civeira

Affiliation:

Keywords: Dyslipidemia, Hypercholesterolemia, Lipid-lowering therapies, Non-cholesterol sterols, Phytosterols, Plant sterols.

Abstract: Non-cholesterol sterols have been used as markers of cholesterol intestinal absorption and hepatic synthesis, leading to a better understanding of cholesterol homeostasis in humans. This review discusses the main noncholesterol sterols that are clinically useful, different methods to quantify the factors associated with blood concentration, and the potential role of non-cholesterol sterols in the diagnosis and treatment of different types of dyslipidemia. The main indication is the use of non-cholesterol sterols for the diagnosis of rare diseases associated with defects in cholesterol synthesis or anomalies in the absorption and/or elimination of phytosterols. However, other potential uses, including the diagnosis of certain hypercholesterolemias and the individualization of lipid-lowering therapies, are promising as they could help treat a wider population.

Cite this article as:

Baila-Rueda Lucía, Cenarro Ana and Civeira Fernando, Non-cholesterol Sterols in the Diagnosis and Treatment of Dyslipidemias: A Review, Current Medicinal Chemistry 2016; 23 (20) . https://dx.doi.org/10.2174/0929867323666160504104133