Abstract
Recent studies show that enhanced mitochondrial biogenesis can “fuel” the cancer cells to grow and migrate. It is therefore proposed that inhibiting the mitochondrial biogenesis could be a new approach to cancer therapy. This review summarizes recent patents and papers in the development of small molecule inhibitors of key regulators responsible for tumor mitochondrial biogenesis, including PPARγcoactivator-1α(PGC-1α), PPARγcoactivator-1β, estrogen-related receptor family (ERRs), estrogen receptor α(ERα), mammalian target of rapamycin, c-Myc and PPARs.
Keywords: Cancer, energy metabolism, inhibitors, mitochondrial biogenesis, PGC-1α, tumor migration.
Recent Patents on Anti-Cancer Drug Discovery
Title:Mitochondrial Biogenesis Inhibitors for Anticancer Therapy: A Review of Recent Patents
Volume: 11 Issue: 3
Author(s): Jinzheng Wang, Xiaoan Wen, Jun Liu and Hongbin Sun
Affiliation:
Keywords: Cancer, energy metabolism, inhibitors, mitochondrial biogenesis, PGC-1α, tumor migration.
Abstract: Recent studies show that enhanced mitochondrial biogenesis can “fuel” the cancer cells to grow and migrate. It is therefore proposed that inhibiting the mitochondrial biogenesis could be a new approach to cancer therapy. This review summarizes recent patents and papers in the development of small molecule inhibitors of key regulators responsible for tumor mitochondrial biogenesis, including PPARγcoactivator-1α(PGC-1α), PPARγcoactivator-1β, estrogen-related receptor family (ERRs), estrogen receptor α(ERα), mammalian target of rapamycin, c-Myc and PPARs.
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Cite this article as:
Wang Jinzheng, Wen Xiaoan, Liu Jun and Sun Hongbin, Mitochondrial Biogenesis Inhibitors for Anticancer Therapy: A Review of Recent Patents, Recent Patents on Anti-Cancer Drug Discovery 2016; 11 (3) . https://dx.doi.org/10.2174/1574892811666160418123628
DOI https://dx.doi.org/10.2174/1574892811666160418123628 |
Print ISSN 1574-8928 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3970 |
Call for Papers in Thematic Issues
Novel anti-cancer drugs in photoimmunotherapy management: from bench to translational research
In recent years, traditional cancer treatments, such as surgery, chemotherapy, and radiation treatment, etc., may damage the pathological tissue and normal cells. The ideal tumor treatment should be noninvasive, eliminating the primary tumor, making the body produce systemic tumor-specific immunity, eliminating metastases, and having less /no side effects. Recent Patents ...read more
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