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Infectious Disorders - Drug Targets

Editor-in-Chief

ISSN (Print): 1871-5265
ISSN (Online): 2212-3989

Bacterial Multidrug Efflux Pumps of the Major Facilitator Superfamily as Targets for Modulation

Author(s): Sanath Kumar, Guixin He, Prathusha Kakarla, Ugina Shrestha, Ranjana KC, Indrika Ranaweera, T. Mark Willmon, Sharla R. Barr, Alberto J. Hernandez and Manuel F. Varela

Volume 16, Issue 1, 2016

Page: [28 - 43] Pages: 16

DOI: 10.2174/1871526516666160407113848

Price: $65

Abstract

Causative agents of infectious disease that are multidrug resistant bacterial pathogens represent a serious public health concern due to the increasingly difficult nature of achieving efficacious clinical treatments. Of the various acquired and intrinsic antimicrobial agent resistance determinants, integral-membrane multidrug efflux pumps of the major facilitator superfamily constitute a major mechanism of bacterial resistance. The major facilitator superfamily (MFS) encompasses thousands of known related secondary active and passive solute transporters, including multidrug efflux pumps, from bacteria to humans. This review article addresses recent developments involving the targeting by various modulators of bacterial multidrug efflux pumps from the major facilitator superfamily. It is currently of tremendous interest to modulate bacterial multidrug efflux pumps in order to eventually restore the clinical efficacy of therapeutic agents against recalcitrant bacterial infections. Such MFS multidrug efflux pumps are good targets for modulation.

Keywords: Antimicrobial agents, bacterial pathogens, drug targets, efflux pump modulation, infection, major facilitator superfamily, multidrug resistance.


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