Abstract
Apathy is an early and common neuropsychiatric syndrome in Alzheimer’s disease (AD) patients. In clinical trials, apathy is associated with decreased motor activity that can be monitored by actigraphy. The triple transgenic mouse AD model (3xTgAD) has been shown to recapitulate the biochemical lesions as well as many of the synaptic and cognitive alterations associated with AD. In the present work we found that these mice also develop an early and consistent apathy-like behavior as evidenced by a drastic decrease in spontaneous activity measured by actimetry. We recently established that these mice also display an intraneuronal accumulation of the β-secretase-derived βAPP fragment (C99) appearing early, in absence of Aβ. Interestingly, we found that the apathy-like behavior observed in 3xTgAD mice was temporally associated with C99 accumulation and synaptic alterations. Since it is well known that the genetic background can strongly influence behavior and can induce transcriptional variability in animal models, we decided to determine the influence of genetic background on the above-described alterations. We backcrossed 3xTgAD mice to C57BL/6 and found that the genetic background had no influence on either C99 accumulation or synaptic plasticity alterations, but strongly affected the apathy-like behavior.
Keywords: Apathy, behavior, C99, LTP, immunohistochemistry, triple transgenic mice, genetic background.
Current Alzheimer Research
Title:Influence of Genetic Background on Apathy-Like Behavior in Triple Transgenic AD Mice
Volume: 13 Issue: 8
Author(s): R. Pardossi-Piquard, I. Lauritzen, C. Bauer, G. Sacco, P. Robert and F. Checler
Affiliation:
Keywords: Apathy, behavior, C99, LTP, immunohistochemistry, triple transgenic mice, genetic background.
Abstract: Apathy is an early and common neuropsychiatric syndrome in Alzheimer’s disease (AD) patients. In clinical trials, apathy is associated with decreased motor activity that can be monitored by actigraphy. The triple transgenic mouse AD model (3xTgAD) has been shown to recapitulate the biochemical lesions as well as many of the synaptic and cognitive alterations associated with AD. In the present work we found that these mice also develop an early and consistent apathy-like behavior as evidenced by a drastic decrease in spontaneous activity measured by actimetry. We recently established that these mice also display an intraneuronal accumulation of the β-secretase-derived βAPP fragment (C99) appearing early, in absence of Aβ. Interestingly, we found that the apathy-like behavior observed in 3xTgAD mice was temporally associated with C99 accumulation and synaptic alterations. Since it is well known that the genetic background can strongly influence behavior and can induce transcriptional variability in animal models, we decided to determine the influence of genetic background on the above-described alterations. We backcrossed 3xTgAD mice to C57BL/6 and found that the genetic background had no influence on either C99 accumulation or synaptic plasticity alterations, but strongly affected the apathy-like behavior.
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Cite this article as:
Pardossi-Piquard R., Lauritzen I., Bauer C., Sacco G., Robert P. and Checler F., Influence of Genetic Background on Apathy-Like Behavior in Triple Transgenic AD Mice, Current Alzheimer Research 2016; 13 (8) . https://dx.doi.org/10.2174/1567205013666160404120106
DOI https://dx.doi.org/10.2174/1567205013666160404120106 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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