Abstract
Research has been lately prospering in the field of Janus nanoparticles, focusing on new synthesis techniques and their application in various fields. This is due to the unique characteristics possessed by this type of particles such as their anisotropic nature, and their synergistic potential for combination therapy in addition to the multilevel targeting. These unique features are essential in several biomedical applications, especially the controlled drug delivery. Various techniques have been used for the synthesis of Janus nanoparticles including; masking, self-assembly, microfluidic and phase separation. They are all aiming at production of uniformly sized Janus particles with spatially separated functionalities. Herein, the main synthesis approaches of various Janus nanoparticles are briefly reviewed with the provision of examples of studies focusing on the potential applications of Janus particles in controlled drug delivery.
Keywords: Janus, nanoparticles, nanocapsules, nanomotors, microfluidic, drug delivery.
Current Pharmaceutical Biotechnology
Title:Janus Nano- and Microparticles as Smart Drug Delivery Systems
Volume: 17 Issue: 8
Author(s): Ibrahim M. El-Sherbiny and Yasmine Abbas
Affiliation:
Keywords: Janus, nanoparticles, nanocapsules, nanomotors, microfluidic, drug delivery.
Abstract: Research has been lately prospering in the field of Janus nanoparticles, focusing on new synthesis techniques and their application in various fields. This is due to the unique characteristics possessed by this type of particles such as their anisotropic nature, and their synergistic potential for combination therapy in addition to the multilevel targeting. These unique features are essential in several biomedical applications, especially the controlled drug delivery. Various techniques have been used for the synthesis of Janus nanoparticles including; masking, self-assembly, microfluidic and phase separation. They are all aiming at production of uniformly sized Janus particles with spatially separated functionalities. Herein, the main synthesis approaches of various Janus nanoparticles are briefly reviewed with the provision of examples of studies focusing on the potential applications of Janus particles in controlled drug delivery.
Export Options
About this article
Cite this article as:
El-Sherbiny M. Ibrahim and Abbas Yasmine, Janus Nano- and Microparticles as Smart Drug Delivery Systems, Current Pharmaceutical Biotechnology 2016; 17 (8) . https://dx.doi.org/10.2174/1389201017666160401145438
DOI https://dx.doi.org/10.2174/1389201017666160401145438 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |
Call for Papers in Thematic Issues
Artificial Intelligence in Bioinformatics
Bioinformatics is an interdisciplinary field that analyzes and explores biological data. This field combines biology and information system. Artificial Intelligence (AI) has attracted great attention as it tries to replicate human intelligence. It has become common technology for analyzing and solving complex data and problems and encompasses sub-fields of machine ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Arsenic Trioxide Exerts Anti-lung Cancer Activity by Inhibiting Angiogenesis
Current Cancer Drug Targets Interaction of Treatment and Biomarker in Advanced Non-small Cell Lung Cancer
Reviews on Recent Clinical Trials Circulating Tumor Cells in Cancer Therapy: Are we off Target?
Current Cancer Drug Targets Recent Advances in the Treatment of Interstitial Lung Disease in Patients with Polymyositis/Dermatomyositis
Endocrine, Metabolic & Immune Disorders - Drug Targets Clinical Pharmacology of Serotonin Receptor Type 3 (5-HT3) Antagonists
Current Medicinal Chemistry - Central Nervous System Agents Metastatic Breast Cancer, Organotropism and Therapeutics: A Review
Current Cancer Drug Targets Cytotoxic Properties of Clofibrate and other Peroxisome Proliferators: Relevance to Cancer Progression
Current Medicinal Chemistry 13C Metabolomics: NMR and IROA for Unknown Identification
Current Metabolomics Synthetic and Natural Coumarins as Cytotoxic Agents
Current Medicinal Chemistry - Anti-Cancer Agents Recent Development of Drug Delivery Systems for the Treatment of Asthma and Related Disorders
Recent Patents on Inflammation & Allergy Drug Discovery RhoGEFs in Cell Motility: Novel Links Between Rgnef and Focal Adhesion Kinase
Current Molecular Medicine Higher Levels of Dynamin-related Protein 1 are Associated with Reduced Radiation Sensitivity of Glioblastoma Cells
Current Neurovascular Research Challenges & Outcome of Thoracic Surgery in a Resource Constrained Developing African Country
Current Respiratory Medicine Reviews Introduction: MMPs, ADAMs/ADAMTSs Research Products to Achieve Big Dream
Anti-Cancer Agents in Medicinal Chemistry Anti-Angiogenic Peptides for Cancer Therapeutics
Current Pharmaceutical Biotechnology Novobiocin Analogs as Potential Anticancer Agents
Mini-Reviews in Medicinal Chemistry Helper T Cells Point the Way to Specific Immunotherapy for Autoimmune Disease
Cardiovascular & Hematological Disorders-Drug Targets Pyruvate Kinase M2: Regulatory Circuits and Potential for Therapeutic Intervention
Current Pharmaceutical Design A Novel Fusicoccin Derivative Preferentially Targets Hypoxic Tumor Cells and Inhibits Tumor Growth in Xenografts
Anti-Cancer Agents in Medicinal Chemistry A Comparison of Physicochemical Property Profiles of Marketed Oral Drugs and Orally Bioavailable Anti-Cancer Protein Kinase Inhibitors in Clinical Development
Current Topics in Medicinal Chemistry