Abstract
Diels Alder cycloaddition is one of the most valuable reactions in organic chemistry for the building of cyclic systems. Recent advances in metabolic engineering, computational methods and chemical biology in general, have allowed designing new artificial enzymes. Apart from, metal and simple organic catalysts more complex catalytic systems based on proteins, RNA and DNA fragments have been demonstrated to be active as Diels- Alderases. This review covers selected advances in the field of artificial enzyme-catalyzed Diels-Alder reaction in last two decades.
Keywords: Antibody catalysis, de novo computational enzyme design, Diels Alderase, Diels-Alder reaction, DNA catalysis, mechanistic studies, RNA catalysis.
Current Organic Chemistry
Title:Artificial Enzyme-Catalyzed Diels-Alder Cycloadditions
Volume: 20 Issue: 21
Author(s): Kevin Cottet, Maria Kolympadi, Marie-Christine Lallemand and Dean Markovic
Affiliation:
Keywords: Antibody catalysis, de novo computational enzyme design, Diels Alderase, Diels-Alder reaction, DNA catalysis, mechanistic studies, RNA catalysis.
Abstract: Diels Alder cycloaddition is one of the most valuable reactions in organic chemistry for the building of cyclic systems. Recent advances in metabolic engineering, computational methods and chemical biology in general, have allowed designing new artificial enzymes. Apart from, metal and simple organic catalysts more complex catalytic systems based on proteins, RNA and DNA fragments have been demonstrated to be active as Diels- Alderases. This review covers selected advances in the field of artificial enzyme-catalyzed Diels-Alder reaction in last two decades.
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Cite this article as:
Cottet Kevin, Kolympadi Maria, Lallemand Marie-Christine and Markovic Dean, Artificial Enzyme-Catalyzed Diels-Alder Cycloadditions, Current Organic Chemistry 2016; 20 (21) . https://dx.doi.org/10.2174/1385272820666160331234851
DOI https://dx.doi.org/10.2174/1385272820666160331234851 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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