Abstract
The Diels-Alder cycloaddition is one of the most utilized reactions for the construction of cyclic systems with high regio-, chemo- and stereoselectivity. Accordingly, this versatile reaction has been broadly exploited in synthetic organic chemistry for the transformation of natural products, structurally diverse molecules of biological interests, pharmaceuticals, polymers and new materials. Nature has also used this cycloaddition reaction and Diels Alderase enzymes were proposed in many biosynthetic pathways of secondary metabolites. The aim of this account is to furnish to the scientific community an overview of reactions using a Diels Alderase for natural product biosynthesis. The proposed biosynthetic pathways involving Diels-Alder reaction are also summarized.
Keywords: Natural products, biosynthesis, putative, Diels-Alder reaction.
Current Organic Chemistry
Title:Natural Products Biosynthesis Involving a Putative Diels-Alder Reaction
Volume: 20 Issue: 22
Author(s): Kévin Cottet, Maria Kolympadi, Dean Markovic and Marie-Christine Lallemand
Affiliation:
Keywords: Natural products, biosynthesis, putative, Diels-Alder reaction.
Abstract: The Diels-Alder cycloaddition is one of the most utilized reactions for the construction of cyclic systems with high regio-, chemo- and stereoselectivity. Accordingly, this versatile reaction has been broadly exploited in synthetic organic chemistry for the transformation of natural products, structurally diverse molecules of biological interests, pharmaceuticals, polymers and new materials. Nature has also used this cycloaddition reaction and Diels Alderase enzymes were proposed in many biosynthetic pathways of secondary metabolites. The aim of this account is to furnish to the scientific community an overview of reactions using a Diels Alderase for natural product biosynthesis. The proposed biosynthetic pathways involving Diels-Alder reaction are also summarized.
Export Options
About this article
Cite this article as:
Cottet Kévin, Kolympadi Maria, Markovic Dean and Lallemand Marie-Christine, Natural Products Biosynthesis Involving a Putative Diels-Alder Reaction, Current Organic Chemistry 2016; 20 (22) . https://dx.doi.org/10.2174/1385272820666160331234709
DOI https://dx.doi.org/10.2174/1385272820666160331234709 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Advances of Heterocyclic Chemistry with Pesticide Activity
Global food safety and security will continue to be a global concern for the next 50 years and beyond. Plant diseases have had a significant impact on food safety and security throughout the entire food chain, from primary production to consumption. While conventional chemical pesticides have been traditionally used for ...read more
Calculation design of covalent/metal organic framework based catalysts
This research area combines theoretical computation and screening with machine learning for the design of covalent/metal organic framework-based catalysts, bridging the disciplines of organic chemistry, physical chemistry, computational chemistry, materials science, and machine learning. It covers several critical aspects: designing and synthesizing organic catalysts for improved performance, applying computational methods ...read more
Carbohydrates conversion in biofuels and bioproducts
Biomass pretreatment, hydrolysis, and saccharification of carbohydrates, and sugars bioconversion in biofuels and bioproducts within a biorefinery framework. Carbohydrates derived from woody biomass, agricultural wastes, algae, sewage sludge, or any other lignocellulosic feedstock are included in this issue. Simulation, techno-economic analysis, and life cycle analysis of a biorefinery process are ...read more
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Protein Glycation: An Old Villain is Shedding Secrets
Combinatorial Chemistry & High Throughput Screening Isoform Selective Phosphoinositide 3-Kinase γ and δ Inhibitors and Their Therapeutic Potential
Recent Patents on Inflammation & Allergy Drug Discovery Chemical Modifications of Ketoprofen (NSAID) in Search of Better Lead Compounds: A Review of Literature From 2004-2016
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Taking Advantage of Viral Immune Evasion: Virus-Derived Proteins Represent Novel Biopharmaceuticals
Current Medicinal Chemistry Prevalence of Anti-nuclear and Anti-phospholipid Antibodies in an Egyptian Cohort with Schizophrenia: A Case-control Study
Current Rheumatology Reviews Restoration of Antitumor Immunity Through Selective Inhibition of Myeloid Derived Suppressor Cells by Anticancer Therapies
Current Molecular Medicine Biological Markers for Multiple Sclerosis
Current Medicinal Chemistry Indoleamine 2,3-dioxygenase as a Modifier of Pathogenic Inflammation in Cancer and other Inflammation-Associated Diseases
Current Medicinal Chemistry Leukocyte Function-Associated Antigen-1: Structure, Function and Application Prospects
Protein & Peptide Letters Probiotics, Immune Function, Infection and Inflammation: A Review of the Evidence from Studies Conducted in Humans
Current Pharmaceutical Design Aminophosphonate Metal Complexes of Biomedical Potential
Current Medicinal Chemistry Recent Patents in siRNA Delivery Employing Nanoparticles as Delivery Vectors
Recent Patents on DNA & Gene Sequences A Review of Clinical Trials of Belimumab in the Management of Systemic Lupus Erythematosus
Current Pharmaceutical Design Editorial: Teratology and Reproductive Toxicology of Anticancer Agents
Anti-Cancer Agents in Medicinal Chemistry Artificial Intelligence, Big Data and Machine Learning Approaches in Precision Medicine & Drug Discovery
Current Drug Targets Imaging Characteristics of Spondyloarthropathy
Current Rheumatology Reviews Newer Insights in Personalized and Evidence Based Medicine- the Role of MicroRNAs
Current Pharmacogenomics and Personalized Medicine Transdermal Anti-inflammatory Delivery for Solid Lipid Nanoparticles of Ketoprofen by Microwave-assisted Microemulsion
Recent Advances in Inflammation & Allergy Drug Discovery Metallic-Based Micro and Nanostructures with Antimicrobial Activity
Current Topics in Medicinal Chemistry Interstitial Lung Disease in Sjogrens Syndrome
Current Rheumatology Reviews