Abstract
Inflammation plays a pivotal role in the ischemia/reperfusion (I/R) injury. Inflammatory response is initiated by the detection of pathogen-associated molecular patterns and/or damage-associated molecular patterns via extracellular and intracellular pattern recognition receptors. The nucleotide-binding oligomerization domain–like receptor family, pyrin domain containing protein 3 (NLRP3) is a component of pattern recognition receptors and serves a vital role in inflammatory response by forming an intracellular multi-protein complex known as NLRP3 inflammasome. There is increasing evidence that NLRP3 inflammasome acts as guardians against host-derived danger materials. The inappropriate activation of NLRP3 contributes to the progression of I/R injury such as myocardial, cerebral, renal, hepatic and retinal I/R injuries. In this review, we summarize the role of NLRP3 in inflammatory response and discuss the relationship between NLRP3 and I/R injury. We also provide insights into new treatment strategies for targeting NLRP3 inflammasome, as well as the upstream and downstream components of NLRP3 in alleviating I/R injury.
Keywords: Inflammasome, ischemia/reperfusion injury, NLRP3, treatment, targets.
CNS & Neurological Disorders - Drug Targets
Title:NLRP3 Is Involved in Ischemia/Reperfusion Injury
Volume: 15 Issue: 6
Author(s): Zhiliang Guo, Shuhong Yu, Xin Chen, Ruidong Ye, Wusheng Zhu and Xinfeng Liu
Affiliation:
Keywords: Inflammasome, ischemia/reperfusion injury, NLRP3, treatment, targets.
Abstract: Inflammation plays a pivotal role in the ischemia/reperfusion (I/R) injury. Inflammatory response is initiated by the detection of pathogen-associated molecular patterns and/or damage-associated molecular patterns via extracellular and intracellular pattern recognition receptors. The nucleotide-binding oligomerization domain–like receptor family, pyrin domain containing protein 3 (NLRP3) is a component of pattern recognition receptors and serves a vital role in inflammatory response by forming an intracellular multi-protein complex known as NLRP3 inflammasome. There is increasing evidence that NLRP3 inflammasome acts as guardians against host-derived danger materials. The inappropriate activation of NLRP3 contributes to the progression of I/R injury such as myocardial, cerebral, renal, hepatic and retinal I/R injuries. In this review, we summarize the role of NLRP3 in inflammatory response and discuss the relationship between NLRP3 and I/R injury. We also provide insights into new treatment strategies for targeting NLRP3 inflammasome, as well as the upstream and downstream components of NLRP3 in alleviating I/R injury.
Export Options
About this article
Cite this article as:
Guo Zhiliang, Yu Shuhong, Chen Xin, Ye Ruidong, Zhu Wusheng and Liu Xinfeng, NLRP3 Is Involved in Ischemia/Reperfusion Injury, CNS & Neurological Disorders - Drug Targets 2016; 15 (6) . https://dx.doi.org/10.2174/1871527315666160321111829
DOI https://dx.doi.org/10.2174/1871527315666160321111829 |
Print ISSN 1871-5273 |
Publisher Name Bentham Science Publisher |
Online ISSN 1996-3181 |
Call for Papers in Thematic Issues
Diagnosis and treatment of central nervous system infectious diseases
Infectious diseases of the central nervous system (CNS) can be divided into bacterial, tuberculous, viral, fungal, parasitic infections, etc. Early etiological treatment is often the most crucial means to reduce the mortality rate of patients with central nervous system infections, reduce complications and sequelae, and improve prognosis. The initial clinical ...read more
Techniques of Drug Repurposing: Delivering a new life to Herbs & Drugs
Of late, with the adaptation of innovative approaches and integration of advancements made towards medical sciences as well as the availability of a wide range of tools; several therapeutic challenges are being translated into viable clinical solutions, with a high degree of efficacy, safety, and selectivity. With a better understanding ...read more
Trends and perspectives in the rational management of CNS disorders
Central nervous system (CNS) diseases enforce a significant global health burden, driving ongoing efforts to improve our understanding and effectiveness of therapy. This issue investigates current advances in the discipline, focusing on the understanding as well as therapeutic handling of various CNS diseases. The issue covers a variety of diseases, ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Fetal Origins of Cardiovascular Disease
Current Cardiology Reviews Erratum
Current Medicinal Chemistry Diabetes and Chronic Heart Failure: From Diabetic Cardiomyopathy to Therapeutic Approach
Endocrine, Metabolic & Immune Disorders - Drug Targets Targeting of Nuclear Factor-κB and Proteasome by Dithiocarbamate Complexes with Metals
Current Pharmaceutical Design The Rise and Fall of NMDA Antagonists for Ischemic Stroke
Current Molecular Medicine Mitochondriotropic Cationic Vesicles A Strategy Towards Mitochondrial Gene Therapy
Current Pharmaceutical Biotechnology The CX3C-Chemokine Fractalkine in Kidney Diseases
Mini-Reviews in Medicinal Chemistry Potential Therapeutic Targeting of Platelet-Mediated Cellular Interactions in Atherosclerosis and Inflammation
Current Medicinal Chemistry Novel Pharmacologic Strategies to Protect the Liver from Ischemia- Reperfusion Injury
Recent Patents on Cardiovascular Drug Discovery Mitochondrial Calcium Signaling as a Therapeutic Target for Alzheimer’s Disease
Current Alzheimer Research Vascular effects of flavonoids
Current Medicinal Chemistry Meet our Editor (Pharmacology)
Current Chinese Science Regulation of Oxidative Stress and Cardioprotection in Diabetes Mellitus
Current Cardiology Reviews Potential Therapeutics for Vascular Cognitive Impairment and Dementia
Current Neuropharmacology Anaemia, Polycythaemia and Chronic Heart Failure
Current Cardiology Reviews Aquaporin and Vascular Diseases
Current Neuropharmacology IL-17A and Multiple Sclerosis: Signaling Pathways, Producing Cells and Target Cells in the Central Nervous System
Current Drug Targets Mechanisms of Immune Modulation by Mesenchymal Stromal Cells and Clinical Translation
Current Molecular Medicine Vascular Endothelial Growth Factor in Central Nervous System Injuries – A Vascular Growth Factor Getting Nervous?
Current Neurovascular Research Role of Oxidative Stress and Mitochondrial Dysfunction in Skeletal Muscle in Type 2 Diabetic Patients
Current Pharmaceutical Design